CAS 828-27-3

4-(Trifluoromethoxy)phenol

Description:

4-(Trifluoromethoxy)phenol, with the CAS number 828-27-3, is an organic compound characterized by the presence of a phenolic hydroxyl group (-OH) and a trifluoromethoxy group (-O-CF3) attached to the para position of the phenol ring. This compound is typically a white to off-white solid at room temperature and is known for its distinctive properties due to the electronegative trifluoromethoxy substituent, which can influence its reactivity and solubility. The trifluoromethoxy group enhances the compound's lipophilicity and can affect its biological activity, making it of interest in various fields, including pharmaceuticals and agrochemicals. Additionally, 4-(Trifluoromethoxy)phenol exhibits moderate to high stability under standard conditions, but it may undergo reactions typical of phenolic compounds, such as oxidation or substitution. Its unique structure allows for potential applications in the synthesis of more complex molecules and in the development of materials with specific electronic or chemical properties.

Formula: C₇H₅F₃O₂

InChI: InChI=1S/C7H5F3O2/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4,11H

InChI key: InChIKey=WDRJNKMAZMEYOF-UHFFFAOYSA-N

SMILES: O(C(F)(F)F)C1=CC=C(O)C=C1

Synonyms:

• 2-Fluoro-1,4-Dimethoxybenzene
• 4-(Trifluormethoxy)benzolol
• 4-Trifluoromethoxyphenol
• Phenol, 4-(trifluoromethoxy)-
• Phenol, p-(trifluoromethoxy)-
• Qr Doxfff
• p-Trifluoromethoxy phenol
• 4-(trifluoromethoxy)phenole
• 4-(Trifluoromethoxy)phenol

4-(Trifluoromethoxy)phenol

CAS: 828-27-3

Formula: C₇H₅F₃O₂

Purity: >95.0%(GC)

Color and Shape: Light yellow to Yellow to Orange clear liquid

Molecular weight: 178.11

Ref: 3B-T1341

4-(Trifluoromethoxy)phenol

CAS: 828-27-3

Formula: C₇H₅F₃O₂

Purity: 98%

Color and Shape: Liquid

Molecular weight: 178.1086

Ref: IN-DA0033U3

4-(Trifluoromethoxy)phenol

CAS: 828-27-3

Formula: C₇H₅F₃O₂

Purity: 98.0%

Color and Shape: Liquid

Molecular weight: 178.11

Ref: 10-F001424

4-(Trifluoromethoxy)phenol

CAS: 828-27-3

4-(Trifluoromethoxy)phenol

Formula: C₇H₅F₃O₂

Purity: 98%

Color and Shape: clear. light green to yellow liquid

Molecular weight: 178.11g/mol

Ref: 54-PC7439M

4-(Trifluoromethoxy)phenol

CAS: 828-27-3

4-(Trifluoromethoxy)phenol is an anti-tuberculosis drug. It is a diode that has been shown to have pharmacokinetic properties in rats and mice. 4-(Trifluoromethoxy)phenol has been shown to act as a prodrug, which is activated by conversion to the active form. This active form inhibits the growth of Mycobacterium tuberculosis by binding to the 50S ribosomal subunit and preventing bacterial transcription and replication. The molecular structure of 4-(trifluoromethoxy)phenol is similar to phenoxypropanoid compounds, such as biphenyl, which may be responsible for its anti-tuberculosis effects. 4-(Trifluoromethoxy)phenol also binds DNA at specific sites with high affinity and specificity, inhibiting gene expression and RNA synthesis.

Formula: C₇H₅F₃O₂

Purity: Min. 95%

Color and Shape: Clear Liquid

Molecular weight: 178.11 g/mol

Ref: 3D-FT64442

4-(Trifluoromethoxy)phenol

Controlled Product

CAS: 828-27-3

Applications 4-(Trifluoromethoxy)phenol is used as a reactant in the preparation of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors.
References Guo, X., et. al.: Eur. J. Med. Chem., 81 (2014)

Formula: C₇H₅F₃O₂

Color and Shape: Neat

Molecular weight: 178.11

Ref: TR-T790885