CAS 82857-69-0

Benzylacyclouridine

Description:

Benzylacyclouridine is a synthetic nucleoside analog that has garnered interest in the field of medicinal chemistry, particularly for its potential antiviral and anticancer properties. It is characterized by a unique structure that combines a benzyl group with an acyclouridine backbone, which contributes to its biological activity. The compound exhibits a modified sugar moiety, which enhances its stability and bioavailability compared to natural nucleosides. Benzylacyclouridine has been studied for its ability to inhibit viral replication and may interfere with nucleic acid synthesis in various pathogens. Its mechanism of action often involves the incorporation into viral RNA or DNA, leading to termination of nucleic acid chain elongation. Additionally, the compound's lipophilic nature, due to the benzyl group, may facilitate its cellular uptake. Research continues to explore its therapeutic potential, optimal dosing, and side effects, making it a subject of interest in drug development and pharmacology. Overall, Benzylacyclouridine represents a significant advancement in the design of nucleoside analogs for therapeutic applications.

Formula: C₁₄H₁₆N₂O₄

InChI: InChI=1S/C14H16N2O4/c17-6-7-20-10-16-9-12(13(18)15-14(16)19)8-11-4-2-1-3-5-11/h1-5,9,17H,6-8,10H2,(H,15,18,19)

InChI key: InChIKey=SPJAGILXQBHHSZ-UHFFFAOYSA-N

SMILES: C(C1=CN(COCCO)C(=O)NC1=O)C2=CC=CC=C2

Synonyms:

• 1-[(2-Hydroxyethoxy)methyl]-5-(phenylmethyl)-2,4(1H,3H)-pyrimidinedione
• 2,4(1H,3H)-Pyrimidinedione, 1-[(2-hydroxyethoxy)methyl]-5-(phenylmethyl)-
• 5-Benzyl-1-(2-hydroxyethoxymethyl)uracil
• 5-Benzylacyclouridine
• Benzylacyclouridine
• BAU

Benzylacyclouridine

CAS: 82857-69-0

Benzylacyclouridine

Molecular weight: 276.29g/mol

Ref: 54-BUP20949

5-Benzyl-1-(2-hydroxyethoxymethyl)uracil

CAS: 82857-69-0

5-Benzyl-1-(2-hydroxyethoxymethyl)uracil is a cytostatic drug that has been shown to inhibit the growth of cancer cells by inhibiting the enzyme activities necessary for DNA replication and transcription. This compound has been found to be effective in treating metastatic colorectal cancer in experimental models, as well as skin cancers in mice. 5-Benzyl-1-(2-hydroxyethoxymethyl)uracil is also an inhibitor of HIV infection, which may be due to its ability to block the synthesis of uridine. The symptoms that are caused by this drug are not yet known.

Formula: C₁₄H₁₆N₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 276.29 g/mol

Ref: 3D-FB139099

Benzylacyclouridine

CAS: 82857-69-0

Benzylacyclouridine (BAU) is a specific UrdPase inhibitor, uridine metabolism and potentiate toxicity of 5-Fu against human prostate cancer cells antitumor.

Formula: C₁₄H₁₆N₂O₄

Color and Shape: Solid

Molecular weight: 276.29

Ref: TM-T40932