CAS 82956-11-4

Nafamostat mesylate

Description:

Nafamostat mesylate is a synthetic serine protease inhibitor primarily used in medical applications, particularly in the treatment of pancreatitis and as an anticoagulant during certain medical procedures. It is characterized by its ability to inhibit various proteases, including trypsin and thrombin, which makes it valuable in managing conditions associated with excessive proteolytic activity. The compound is typically administered intravenously due to its poor oral bioavailability. Nafamostat mesylate is known for its rapid onset of action and relatively short half-life, necessitating continuous infusion in clinical settings. Its chemical structure includes a mesylate group, which enhances its solubility and stability in solution. Additionally, it has garnered attention for potential antiviral properties, particularly in the context of COVID-19, as it may inhibit viral entry by targeting specific proteases involved in the viral life cycle. Overall, Nafamostat mesylate is a versatile compound with significant therapeutic applications, particularly in critical care and experimental treatments.

Formula: C₂₁H₂₅N₅O₈S₂

InChI: InChI=1/C19H17N5O2.CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);1H3,(H,2,3,4)

InChI key: InChIKey=ZESSXQLDESEKGC-UHFFFAOYSA-N

SMILES: C(=N)(N)C1=CC2=C(C=C(OC(=O)C3=CC=C(NC(=N)N)C=C3)C=C2)C=C1.S(C)(=O)(=O)O

Synonyms:

• (E)-amino({4-[({6-[(Z)-ammonio(imino)methyl]naphthalen-2-yl}oxy)carbonyl]phenyl}imino)methanaminium dimethanesulfonate
• 6-Amidino-2-naphthyl 4-guanidino-benzoate dimethanesulphonate
• 6-Amidino-2-naphthyl p-guanidinobenzoate
• 6-Carbamimidoylnaphthalen-2-Yl 4-[(Diaminomethylidene)Amino]Benzoate Methanesulfonate
• Benzoic acid, 4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate
• Benzoic acid, 4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester, methanesulfonate (1:2)
• Coahibitor
• Fut 175
• Futhan
• Nafamastat mesylate
• Nafamostat Mesilate
• Nafamostat dimethanesulfonate
• Nafamostat mesylate
• nafamstatmesilate
• 4-Guanidinobenzoic acid 6-amidino-2-naphtyl·2(methanesulfonic acid)
• Nafomastatmesilate
• 6-AMIDINO-2-NAPHTHYL-4-GUANIDINOBENZOATE DIMETHANESULFONATE
• FUT-175, 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate
• 6-AMIDINO-2-NAPHTHYL-4-GUANIDINOENZOATE, MESYLATE
• ester,dimethanesulfonate
• Nafamstat mesylate
• 4-((aminoiminomethyl)amino)-benzoicaci6-(aminoiminomethyl)-2-naphthalenyl

Nafamostat Mesylate

CAS: 81525-10-2, 82956-11-4

Formula: C₁₉H₁₇N₅O₂·2CH₄O₃S

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 539.58

Ref: 3B-N0959

Benzoic acid, 4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate

CAS: 82956-11-4

Formula: C₂₀H₂₁N₅O₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 443.4762

Ref: IN-DA003SPE

Nafamostat Mesylate

CAS: 82956-11-4

Formula: C₁₉H₁₇N₅O₂·2CH₄O₃S

Molecular weight: 347.38 2*96.11

Ref: 4Z-N-135001

Nafamostat Mesilate (Fut-175)

CAS: 82956-11-4

Nafamostat Mesilate (Fut-175)

Purity: 98%

Molecular weight: 539.58g/mol

Ref: 54-OR1027803

Nafamostat mesylate

CAS: 82956-11-4

Nafamostat mesylate

Purity: ≥95%

Molecular weight: 539.58g/mol

Ref: 54-BUP15097

Nafamostat mesylate

CAS: 82956-11-4

Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis

Formula: C₁₉H₁₇N₅O₂·2CH₄O₃S

Purity: 97.36% - 99.76%

Color and Shape: Tan To Pale Orange Solid

Molecular weight: 539.58

Ref: TM-T2392

Nafamostat mesylate

CAS: 82956-11-4

Formula: C₁₉H₁₇N₅O₂

Purity: ≥ 99.0%

Color and Shape: White to off-white or beige crystalline powder

Molecular weight: 347.37

Ref: 7W-GP5144

6-[amino(imino)methyl]-2-naphthyl 4-{[amino(imino)methyl]amino}benzoate dimethanesulfonate

CAS: 82956-11-4

Purity: 98.0%

Color and Shape: Solid

Molecular weight: 347.378

Ref: 10-F375834

Nafamostat Mesylate

CAS: 82956-11-4

Applications A non-peptide proteaseinhibitor.
References Ayoyama, T., et al.: Chem. Pharm. Bull., 33, 1458 (1985)

Formula: C₁₉H₁₇N₅O₂·2CH₄O₃S

Color and Shape: Neat

Molecular weight: 539.58

Ref: TR-N210000

Nafamostat mesylate

CAS: 82956-11-4

Kallikrein inhibitor; serine protease inhibitor

Formula: C₁₉H₁₇N₅O₂·2CH₃SO₃H

Purity: Min. 98 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 539.58 g/mol

Ref: 3D-FA26119

Nafamostat mesylate - Bio-X ™

CAS: 82956-11-4

Nafamostat is a broad-spectrum serine protease inhibitor produced by chemical synthesis. Nafamostat is effective through its antioxidant and anti-inflammatory activity. This drug is involved in inhibiting various enzyme systems such as coagulation and fibrinolytic systems.

Formula: C₁₉H₁₇N₅O₂•(CH₄O₃S)₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 539.58 g/mol

Ref: 3D-BA164628