CAS 83-12-5
:Phenindione
Description:
Phenindione, with the CAS number 83-12-5, is an organic compound that belongs to the class of anticoagulants, specifically acting as a vitamin K antagonist. It is characterized by its bicyclic structure, which includes a phenyl group fused to a 1,3-dione system. This compound is typically a yellow to orange crystalline solid that is sparingly soluble in water but more soluble in organic solvents such as ethanol and acetone. Phenindione is primarily used in the medical field for its anticoagulant properties, helping to prevent blood clots in various conditions. Its mechanism of action involves inhibiting the synthesis of vitamin K-dependent clotting factors in the liver, thereby affecting the coagulation cascade. Additionally, phenindione may exhibit side effects similar to other anticoagulants, including bleeding risks, and requires careful monitoring of blood coagulation parameters during therapy. Due to its pharmacological significance, phenindione has been studied for its potential interactions with other medications and its overall safety profile in clinical use.
Formula:C15H10O2
InChI:InChI=1/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,16H
InChI key:InChIKey=NFBAXHOPROOJAW-UHFFFAOYSA-N
SMILES:O=C1C(C(=O)C=2C1=CC=CC2)C3=CC=CC=C3
Synonyms:- 1,3-Indandione, 2-phenyl-
- 1H-Indene-1,3(2H)-dione, 2-phenyl-
- 2-Phenyl-1,3-diketohydrindene
- 2-Phenyl-1,3-indanedione
- 2-Phenyl-1H-inden-1,3(2H)-dione
- 2-Phenyl-1H-indene-1,3(2H)-dione
- 2-Phenyl-2,3-dihydro-1H-indene-1,3-dione
- 2-Phenylindandione
- 2-Phenylindene-1,3-dione
- 3-hydroxy-2-phenyl-1H-inden-1-one
- Athrombon
- Bindan
- Cronodione
- Danedion
- Danilon
- Danilone
- Diadilan
- Dindevan
- Dineval
- Diophindane
- Emandion
- Emandione
- Fenhydren
- Fenilin
- Fenindion
- Fenindiona
- Hedulin
- Hemolidione
- Indema
- Indion
- Indon
- Nsc 41693
- PID
- Phenhydren
- Phenillin
- Phenindion
- Phenindione
- Phenylen
- Phenylin
- Phenylindione
- Pindione
- Rectadione
- Theradione
- Thrombasal
- Tromazal
- Trombol
- 2-phenyl-1h-indene-3(2h)-dione
- AURORA KA-4422
- 1,3(2H)-Indenedione, 2-phenyl-
- PHENINDONE
- 2-PHENYL-1,3-INDANDIONE
- 2-Phenyl-indan-1,3-dione
- 2-fenyloindandion-1,3
- 2-phenyl-3-indandione
- 2-phenylindan-1-3-dione
- See more synonyms
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Phenindione
CAS:PhenindioneFormula:C15H10O2Purity:97.3%Color and Shape:WhiteMolecular weight:222.06808Phenindione
CAS:Phenindione, an obsolete anticoagulant with warfarin-like effects, is rarely used due to severe side effects.Formula:C15H10O2Purity:97.68% - 98.17%Color and Shape:White SolidMolecular weight:222.242-Phenyl-1,3-Indandione
CAS:2-Phenyl-1,3-IndandioneFormula:C15H10O2Purity:0.98Molecular weight:222.242-Phenyl-1H-indene-1,3(2H)-dione
CAS:Formula:C15H10O2Purity:98%Color and Shape:SolidMolecular weight:222.23872-Phenyl-1H-indene-1,3(2H)-dione
CAS:2-Phenyl-1H-indene-1,3(2H)-dioneFormula:C15H10O2Purity:98%Molecular weight:222.242-Phenyl-1,3-indandione
CAS:2-Phenyl-1,3-indandione is a coumarin derivative that is used as an anti-inflammatory drug. It inhibits the release of arachidonic acid from phospholipids in the cell membrane and consequently inhibits the formation of prostaglandins. The drug has been shown to inhibit light-induced tumor promotion in mice with cervical cancer, which may be due to its ability to inhibit the activity of oxidative enzymes such as cytochrome P450. 2-Phenyl-1,3-indandione also inhibits sodium-dependent glucose transport and energy metabolism by binding to potassium channels. This drug also has immunosuppressive effects on lymphocyte transformation and autoimmune diseases through hydrogen bonding interactions with protein molecules.Formula:C15H10O2Purity:Min. 95%Color and Shape:PowderMolecular weight:222.24 g/mol2-Phenyl-1H-indene-1,3(2H)-dione
CAS:Formula:C15H10O2Purity:98%Color and Shape:SolidMolecular weight:222.243Phenindione
CAS:Controlled ProductApplications Phenindione is a proton pump inhibitor and traditional nonsteroidal anti-inflammatory drug used for acute interstitial nephritis and acute kidney injury.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Leonard, C.E., et al.: Pharmacoepidemiol. Drug. Safety., 21, 1155 (2012); Moda, T.L., et al.: Bioorg. Med. Chem. Lett., 22, 2889 (2012); Dhareshwar, S.S., et al.: J. Pharma. Sci., 99, 2711 (2010);Formula:C15H10O2Color and Shape:NeatMolecular weight:222.24
