CAS 83105-70-8

Sultamicillin tosylate

Description:

Sultamicillin tosylate is a semisynthetic antibiotic that combines ampicillin and sulbactam, designed to enhance its efficacy against beta-lactamase-producing bacteria. It is classified as a beta-lactam antibiotic and is primarily used to treat various bacterial infections, particularly those caused by susceptible strains of bacteria. The compound exhibits a broad spectrum of activity against both Gram-positive and Gram-negative organisms. Sultamicillin tosylate is typically administered orally and is known for its favorable pharmacokinetic properties, including good absorption and distribution in body tissues. The tosylate salt form enhances its stability and solubility. As with other antibiotics, it is essential to use sultamicillin tosylate judiciously to prevent the development of antibiotic resistance. Common side effects may include gastrointestinal disturbances, allergic reactions, and, in rare cases, more severe adverse effects. Overall, sultamicillin tosylate represents an important therapeutic option in the management of bacterial infections, particularly in settings where resistance to other antibiotics is a concern.

Formula: C₂₅H₃₀N₄O₉S₂·C₇H₈O₃S

InChI: InChI=1S/C25H30N4O9S2.C7H8O3S/c1-24(2)17(29-20(32)16(21(29)39-24)27-19(31)15(26)12-8-6-5-7-9-12)22(33)37-11-38-23(34)18-25(3,4)40(35,36)14-10-13(30)28(14)18;1-6-2-4-7(5-3-6)11(8,9)10/h5-9,14-18,21H,10-11,26H2,1-4H3,(H,27,31);2-5H,1H3,(H,8,9,10)/t14-,15-,16-,17+,18+,21-;/m1./s1

InChI key: InChIKey=FFCSPKNZHGIDQM-CGAOXQFVSA-N

SMILES: C(OCOC(=O)[C@@H]1N2[C@](S(=O)(=O)C1(C)C)(CC2=O)[H])(=O)[C@@H]3N4[C@@]([C@H](NC([C@H](N)C5=CC=CC=C5)=O)C4=O)(SC3(C)C)[H].S(=O)(=O)(O)C1=CC=C(C)C=C1

Synonyms:

• ({[(2S,5R,6R)-6-{[(2S)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-yl]carbonyl}oxy)methyl (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide 4-methylbenzenesulfonate hydrate (1:1:2)
• ({[(5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-yl]carbonyl}oxy)methyl (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide 4-methylbenzenesulfonate (1:1)
• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, (((3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-2-yl)carboxyl)oxy)methyl ester, S,S-dioxide, p-toluenesulfonate, (2S-(2-alpha(2R*,5S*),5-alpha,6-beta(S*)))-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-, [[(3,3-dimethyl-4,4-dioxido-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-yl)carbonyl]oxy]methyl ester, [2S-[2α(2R*,5S*),5α,6β(S*)]]-, mono(4-methylbenzenesulfonate)
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-, [[(3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-yl)carbonyl]oxy]methyl ester, S,S-dioxide, [2S-[2α(2R*,5S*),5α,6β(S*)]]-, mono(4-methylbenzenesulfonate)
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-aminophenylacetyl]amino]-3,3-dimethyl-7-oxo-, [[[(2S,6R)-3,3-dimethyl-4,4-dioxido-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-yl]carbonyl]oxy]methyl ester, (2S,5R,6R)-, (4-methylbenzenesulfonate) (1:1)
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-aminophenylacetyl]amino]-3,3-dimethyl-7-oxo-, [[[(2S,6R)-3,3-dimethyl-4,4-dioxido-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-yl]carbonyl]oxy]methyl ester, (2S,5R,6R)-, mono(4-methylbenzenesulfonate)
• Bacimex
• Bethacil orale
• CP 49952 p-Toluenesulfonate
• Sbtpc
• Sultamicillin p-toluenesulfonate
• Sultamicillin tosilate
• Unacid PD oral
• Unacim orale
• VD 1827 p-Toluenesulfonate

SULTAMICILLIN TOSILATE CRS

CAS: 83105-70-8

SULTAMICILLIN TOSILATE CRS

Formula: C₃₂H₃₈N₄O₁₂S₃

Molecular weight: 766.8587

Ref: 41-Y0000531

Sultamicillin tosylate

CAS: 83105-70-8

Formula: C₃₂H₃₈N₄O₁₂S₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 766.8587

Ref: IN-DA0036J1

Sultamicillin Tosilate

CAS: 83105-70-8

Sultamicillin Tosilate

Purity: 99%

Molecular weight: 766.86g/mol

Ref: 54-OR1028139

Sultamicillin Tosylate

CAS: 83105-70-8

Sultamicillin Tosylate

Purity: ≥98%

Molecular weight: 766.86g/mol

Ref: 54-BUP17111

Sultamicillin Tosylate Dihydrate

CAS: 76497-13-7, 83105-70-8

Formula: C₂₅H₃₀N₄O₉S₂·C₇H₈O₃S·2H₂O

Purity: >98.0%(GC)(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 802.88

Ref: 3B-U0097

Sultamicillin tosylate

CAS: 83105-70-8

Formula: C₂₅H₃₀N₄O₉S₂·C₇H₈O₃S·xH₂O

Purity: (Titration) 97.0 - 102.0 % (anhydrous, solvent free)

Color and Shape: White to off-white crystalline powder

Molecular weight: 766.85 (anhydrous)

Ref: 7W-GA7670

Sultamicillin Tosylate

CAS: 83105-70-8

Sultamicillin Tosylate (Unacim orale) is an oral form of the antibiotic combination (codrug or mutual prodrug) ampicillin/sulbactam.

Formula: C₃₂H₃₈N₄O₁₂S₃

Purity: 99.04%

Color and Shape: Solid

Molecular weight: 766.86

Ref: TM-T3139

Sultamicillin Tosylate

Controlled Product

CAS: 83105-70-8

Applications Sultamicillin Tosylate is a useful oral antibacterial agent.
References Zeng, X.: Zhongnan Yaoxue, 5, 346 (2007)

Formula: C₂₅H₃₀N₄O₉S₂·C₇H₈O₃S

Color and Shape: Neat

Molecular weight: 766.86

Ref: TR-S789490