CAS 83480-48-2

9-[(2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-fluoro-1H-purin-6-one

Description:

The chemical substance known as 9-[(2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-fluoro-1H-purin-6-one, with the CAS number 83480-48-2, is a purine derivative characterized by the presence of a fluorine atom at the 2-position of the purine ring. This compound features a tetrahydrofuran moiety that is substituted with hydroxyl groups, contributing to its potential biological activity. The stereochemistry of the tetrahydrofuran ring is specified as (2R,3R,5R), indicating the specific spatial arrangement of its substituents, which can influence the compound's interactions with biological targets. The presence of multiple hydroxyl groups suggests that this molecule may exhibit strong hydrogen bonding capabilities, enhancing its solubility in polar solvents and potentially affecting its pharmacokinetic properties. This compound may be of interest in medicinal chemistry, particularly in the development of antiviral or anticancer agents, due to its structural similarity to nucleosides and its potential to interfere with nucleic acid synthesis.

Formula: C₁₀H₁₁FN₄O₅

InChI: InChI=1/C10H11FN4O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H,13,14,19)/t3-,5?,6-,9-/m1/s1

InChI key: RHLSRGWIGPHHJW-VCXQEIDJSA-N

SMILES: C([C@@H]1C([C@H]([C@H](n2cnc3c2nc(F)nc3O)O1)O)O)O

9-β-D-Arabinofuranosyl-2-fluorohypoxanthine

CAS: 83480-48-2

9-β-D-Arabinofuranosyl-2-fluorohypoxanthine is a nucleoside analog that acts as an inhibitor for certain enzymes. It is useful in synthesis and, due to its structural variation, can induce base mismatching, thereby halting chain polymerization reactions.

Formula: C₁₀H₁₁FN₄O₅

Molecular weight: 286.22

Ref: TM-TSW-00626

2-Fluoroinosine

CAS: 83480-48-2

Ref: 7W-GN8682

9-β-D-Arabinofuranosyl-2-fluorohypoxanthine

Controlled Product

CAS: 83480-48-2

Formula: C₁₀H₁₁FN₄O₅

Color and Shape: Neat

Molecular weight: 286.22

Ref: TR-A763800

2-Fluoroinosine

CAS: 83480-48-2

2-Fluoroinosine is a chemical that inhibits protein synthesis by blocking the attachment of amino acids to their corresponding tRNA molecules. This drug is used in the treatment of cancer, as it inhibits cell growth and prevents tumor cells from dividing. 2-Fluoroinosine has been shown to be effective against human leukaemia cells, with its inhibitory properties being due to its ability to dephosphorylate the enzyme RNA polymerase II. This drug also has anti-malarial properties and can be used for the treatment of Chagas disease. 2-Fluoroinosine is synthesized from xanthosine, which is an intermediate in purine metabolism and can be obtained from naturally occurring sources or chemically through a solid phase synthesis. 2-Fluoroinosine is activated by UV light and can be synthesized using single stranded DNA or synthetases such as those found in calf thymus tissue. The catalytic mechanism of this drug has

Formula: C₁₀H₁₁FN₄O₅

Purity: Min. 95%

Molecular weight: 286.22 g/mol

Ref: 3D-NF17964