CAS 835621-11-9

2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, 1-oxide

Description:

2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, 1-oxide, identified by CAS number 835621-11-9, is a synthetic organic compound characterized by its complex molecular structure. It features a pyridine ring, which contributes to its aromatic properties, and multiple functional groups, including amide and ether linkages, which enhance its reactivity and solubility in various solvents. The presence of a trifluoromethyl group and a chloro substituent on the phenyl ring suggests potential applications in pharmaceuticals, particularly in the development of compounds with specific biological activities. The compound's 1-oxide designation indicates the presence of an oxidized nitrogen atom, which may influence its electronic properties and reactivity. Overall, this compound's intricate structure and functional diversity make it a subject of interest in medicinal chemistry and material science, where it may be explored for its potential therapeutic effects or as a building block in drug design.

Formula: C₂₁H₁₅ClF₄N₄O₄

InChI: InChI=1S/C21H15ClF4N4O4/c1-27-19(31)18-10-13(6-7-30(18)33)34-12-3-5-17(16(23)9-12)29-20(32)28-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,28,29,32)

InChI key: NUCXNEKIESREQY-UHFFFAOYSA-N

SMILES: CNC(=O)C1=[N+](C=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F)[O-]

Regorafénib N-oxyde (M2)

CAS: 835621-11-9

Regorafénib N-oxyde M2 is an active metabolite of Regorafenib.

Formula: C₂₁H₁₅ClF₄N₄O₄

Purity: 98.03% - 98.26%

Color and Shape: White Solid

Molecular weight: 498.815

Ref: TM-T10157

Regorafenib N-Oxide (M2 Metabolite)

CAS: 835621-11-9

Formula: C₂₁H₁₅ClF₄N₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 498.82

Ref: 4Z-R-078008

Regorafénib N-oxyde (M2)

CAS: 835621-11-9

Regorafénib N-oxyde (M2)

Formula: C₂₁H₁₅ClF₄N₄O₄

Purity: ≥95%

Molecular weight: 498.81

Ref: 54-BUP12395

Regorafenib N-Oxide-13C-d3 (M2 Metabolite-13C-d3)

CAS: 835621-11-9

Formula: C₂₀₁₃CH₁₂D₃ClF₄N₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 502.83

Ref: 4Z-R-078004

4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide

CAS: 835621-11-9

Purity: 96%

Ref: IN-DA00G3MT

Regorafenib (Pyridine)-N-oxide

Controlled Product

CAS: 835621-11-9

Stability Light Sensitive
Applications Regorafenib (Pyridine)-N-oxide is a synthetic metabolite of Regorafenib (R143000) and is used for treatment and prevention of cancer.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wilhelm, S.: PCT Int. Appl. WO 2011130728 A1 20111020. Oct 20, 2011

Formula: C₂₁H₁₅ClF₄N₄O₄

Color and Shape: Neat

Molecular weight: 498.81

Ref: TR-R143315

Regorafénib N-oxyde (M2)

CAS: 835621-11-9

4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-2-(methylcarbamoyl)pyridine 1-oxide

Formula: C₂₁H₁₅ClF₄N₄O₄

Purity: 96%

Molecular weight: 498.81

Ref: IN-DG00786458

Regorafenib metabolite M2-[13C, d3] (N-oxide)

CAS: 835621-11-9

Formula: C₂₁H₁₅ClF₄N₄O₄

Molecular weight: 498.8

Ref: BE-MCD-7558

Regorafenib metabolite M2 (N-oxide)

CAS: 835621-11-9

Formula: C₂₁H₁₅ClF₄N₄O₄

Molecular weight: 498.8

Ref: BE-MU-7558

Regorafénib N-oxyde (M2)

CAS: 835621-11-9

Formula: C₂₁H₁₅ClF₄N₄O₄

Molecular weight: 498.8

Ref: BE-RMCR030007

Regorafénib N-oxyde M2

CAS: 835621-11-9

Purity: 98%

Molecular weight: 498.82

Ref: 10-F987790

Regorafénib N-oxyde (M2) (Standard)

CAS: 835621-11-9

Regorafénib N-oxyde (M2) (Standard) is a reference standard for research and analysis in studies involving Regorafénib N-oxyde (M2). Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC₅₀s: 13/4.2/46, 1.5, 22, 7, and 2.5 nM).

Formula: C₂₁H₁₅ClF₄N₄O₄

Molecular weight: 498.815

Ref: TM-TMSM-3516

Regorafenib metabolite M2 oxide

CAS: 835621-11-9

Regorafenib metabolite M2 oxide (M2O) is a cancer drug that is an inhibitor of multikinase. It was developed as a prodrug for regorafenib, which is used to treat patients with metastatic colorectal cancer and has been shown to be effective against other cancers, such as lung and pancreatic cancer. M2O inhibits the efflux of drugs from cells by binding to the transporter protein P-glycoprotein. This prevents the accumulation of toxic concentrations of regorafenib in cells, which are responsible for its side effects, such as diarrhea and liver damage. The uptake of M2O by cells is also inhibited by light and acidic conditions. Oral administration of M2O leads to increased exposure to regorafenib in the body because it is not metabolized by CYP3A4 enzymes.

Formula: C₂₁H₁₅ClF₄N₄O₄

Purity: Min. 95%

Molecular weight: 498.81 g/mol

Ref: 3D-IR164114

Regorafenib N-oxide

CAS: 835621-11-9

Formula: C₂₁H₁₅ClF₄N₄O₄

Molecular weight: 498.82

Ref: ST-EA-CP-R59006