CAS 83602-39-5: Cyclosporin H

Description: Cyclosporin H, with the CAS number 83602-39-5, is a cyclic polypeptide that belongs to the class of immunosuppressive agents. It is derived from the fungus Tolypocladium inflatum and is structurally related to cyclosporine A, differing primarily in its amino acid composition. Cyclosporin H exhibits potent immunosuppressive properties, making it valuable in preventing organ transplant rejection and treating autoimmune diseases. Its mechanism of action involves the inhibition of T-cell activation and proliferation by binding to cyclophilin, which subsequently inhibits calcineurin, a critical enzyme in T-cell signaling pathways. The substance is lipophilic, which affects its solubility and bioavailability, and it is typically administered orally or intravenously. Due to its immunosuppressive effects, careful monitoring of patients is essential to manage potential side effects, including increased susceptibility to infections and nephrotoxicity. Overall, Cyclosporin H represents an important therapeutic agent in clinical settings, particularly in transplant medicine.

Formula: C₆₃H₁₁₃N₁₁O₁₂

InChI: InChI=1/C63H113N11O12/c1-26-28-29-41(15)53(76)52-56(79)66-44(27-2)58(81)67(18)34-49(75)68(19)46(31-36(5)6)60(83)72(23)50(39(11)12)62(85)69(20)45(30-35(3)4)55(78)64-42(16)54(77)65-43(17)57(80)70(21)47(32-37(7)8)59(82)71(22)48(33-38(9)10)61(84)73(24)51(40(13)14)63(86)74(52)25/h26,28,35-48,50-53,76H,27,29-34H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)/b28-26+/t41-,42+,43-,44+,45+,46+,47-,48+,50-,51+,52?,53-/m1/s1

Synonyms:

• Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
• (3S,6S,9R,12R,15S,18S,21R,24S,30S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,22,25,28-decamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone

Cyclosporin H

CAS: 83602-39-5

Lactams, nesoi

• Formula: C₆₂H₁₁₁N₁₁O₁₂
• Color and Shape: White Off-White Solid
• Molecular weight: 1201.84137

Cyclosporin H

CAS: 83602-39-5

• Formula: C₆₂H₁₁₁N₁₁O₁₂
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 1202.6112

Cyclosporin H

CAS: 83602-39-5

• Formula: C₆₂H₁₁₁N₁₁O₁₂
• Color and Shape: White To Off-White Solid
• Molecular weight: 1202.64

Cyclosporin H

CAS: 83602-39-5

• Purity: ≥98%
• Molecular weight: 1202.61g/mol

Cyclosporin H

CAS: 83602-39-5

• Formula: C₆₂H₁₁₁N₁₁O₁₂
• Purity: 95%~99%
• Molecular weight: 1202.64

Cyclosporin H

CAS: 83602-39-5

Cyclosporin H inhibits FPR1, reduces lung inflammation and MAPK/AKT activity, boosts viral transduction, and lacks …

• Formula: C₆₂H₁₁₁N₁₁O₁₂
• Purity: 99.87% - 99.94%
• Color and Shape: White Crystalline Power
• Molecular weight: 1202.61

Cyclosporin H

CAS: 83602-39-5

• Formula: C₆₂H₁₁₁N₁₁O₁₂
• Molecular weight: 1202.6

Cyclosporin H

CAS: 83602-39-5

• Formula: C₆₂H₁₁₁N₁₁O₁₂
• Molecular weight: 1202.6

Cyclosporin H

CAS: 83602-39-5

Applications Cyclosporin is an immunosuppressant that has revolutionized organ transplantation through its use in the …

• Formula: C₆₂H₁₁₁N₁₁O₁₂
• Color and Shape: Neat
• Molecular weight: 1202.61

Iso Cyclosporin H Trifluoroacetic Acid Salt

CAS: 83602-39-583602-43-1

Stability Hygroscopic Applications Iso Cyclosporin H is an impurity of Cyclosporin H (C988920). References Borel, …

• Formula: C₆₂H₁₁₁N₁₁O₁₂·x(C₂HF₃O₂)
• Purity: >75% by HPLC
• Color and Shape: Neat
• Molecular weight: 1202.61 + x(114.02)

Cyclosporin H

CAS: 83602-39-5

Formyl peptide receptor-1 (FPR-1) antagonist

• Formula: C₆₂H₁₁₁N₁₁O₁₂
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 1,202.61 g/mol