CAS 83784-20-7

Hydrocortisone hemisuccinate hydrate

Description:

Hydrocortisone hemisuccinate hydrate is a synthetic derivative of hydrocortisone, a corticosteroid hormone. It is characterized by its hemisuccinate ester form, which enhances its solubility and bioavailability compared to the parent compound. This substance typically appears as a white to off-white crystalline powder and is hygroscopic, meaning it can absorb moisture from the environment. It is often used in pharmaceutical formulations, particularly for its anti-inflammatory and immunosuppressive properties. The compound is soluble in water and exhibits stability under proper storage conditions. Hydrocortisone hemisuccinate hydrate is commonly utilized in injectable formulations, making it valuable in clinical settings for treating various conditions, including allergic reactions and inflammatory diseases. Its pharmacological effects are primarily mediated through the modulation of gene expression and the inhibition of pro-inflammatory cytokines. As with all corticosteroids, its use must be carefully monitored to avoid potential side effects associated with long-term administration.

Formula: C₂₅H₃₆O₉

InChI: InChI=1S/C25H34O8.H2O/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);1H2/t16-,17-,18-,22+,23-,24-,25-;/m0./s1

InChI key: AFLWPAGYTPJSEY-CODXZCKSSA-N

SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)COC(=O)CCC(=O)O)O)C)O.O

Synonyms:

• (11b-)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxypregn-4-ene-3,20-dione monohydrate
• HYDROCORTISONEHEMISUCCINATE,MONOHYDRATE,USP
• 11β,17aα,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate
• Hydrocortisone Hemisuccinate (200 mg)
• 4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid hydrate
• 4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethoxy]-4-oxo-butanoic acid hydrate
• Hydrocortisone 21-hemisuccinat
• Hydrocortisone hemisuccinate hydrate USP/EP/BP
• HYDROCORTISONE HEMISUCCINATE, MONOHYDRATE
• 4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-3-keto-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-keto-ethoxy]-4-keto-butyric acid hydrate
• Hydrocortisone hemisuccinate hydrate
• CORTISOL HEMISUCCINATE MONOHYDRATE

HYDROCORTISONE HYDROGEN SUCCINATE CRS

CAS: 83784-20-7

HYDROCORTISONE HYDROGEN SUCCINATE CRS

Formula: C₂₅H₃₄O₈

Color and Shape: Powder

Molecular weight: 462.5327

Ref: 41-H1425000

Hydrocortisone Hemisuccinate

CAS: 83784-20-7

Adrenal cortical hormones and their derivatives

Formula: C₂₅H₃₄O₈·H₂O

Color and Shape: White Off-White Powder

Molecular weight: 462.22537

Ref: 45-1319002

Hydrocortisone hemisuccinate hydrate

CAS: 83784-20-7

Hydrocortisone hemisuccinate hydrate

Formula: C₂₅H₃₆O₉

Purity: 97%

Molecular weight: 480.55

Ref: 54-OR1109458

Hydrocortisone hemisuccinate hydrate

CAS: 83784-20-7

Formula: C₂₅H₃₆O₉

Purity: 97%

Color and Shape: Solid

Molecular weight: 480.5479

Ref: IN-DA00IDBT

Hydrocortisone Hemisuccinate Hydrate

Controlled Product

CAS: 83784-20-7

Applications Hydrocortisone Hemisuccinate Hydrate is a metabolite of Hydrocortisone (H714615), a steroid hormone, specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids.
References Vigore, L., et al.: Cancer Ther., 6, 699 (2008); Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009); Lemos, D., et al.: J. Endocrinol., 201, 275 (2009); Chen, S., et al.: Am. J. Physiol., 296 (2009);

Formula: C₂₅H₃₄O₈·H₂O

Color and Shape: Neat

Molecular weight: 480.55

Ref: TR-H714765

Hydrocortisone succinate monohydrate

CAS: 83784-20-7

Formula: C₂₅H₃₆O₉

Molecular weight: 480.5

Ref: BE-BePure-26380

Hydrocortisone hemisuccinate

Controlled Product

CAS: 83784-20-7

Hydrocortisone hemisuccinate is a corticosteroid that belongs to the group of glucocorticoids. It is used in the treatment of bowel disease, such as ulcerative colitis and Crohn's disease. Hydrocortisone hemisuccinate has been shown to have chemical stability in biological reaction solutions and has an anti-inflammatory activity in animal models. The drug has minimal effects on the maternal blood system and does not produce any significant drug interactions when combined with other drugs. Hydrocortisone hemisuccinate also does not cause allergic symptoms or receptor activity, unlike other corticosteroids such as dexamethasone. This steroid is used for the treatment of erythropoietic protoporphyria, which is a rare disorder where the skin becomes sensitive to sunlight. Hydrocortisone hemisuccinate can be administered at physiological levels and this form of hydrocortisone provides sodium salts as a

Formula: C₂₅H₃₄O₈·H₂O

Purity: Min. 95%

Molecular weight: 480.55 g/mol

Ref: 3D-IDA78420

Hydrocortisone Hemisuccinate Hydrate

CAS: 83784-20-7

Formula: C₂₅H₃₄O₈H₂O

Molecular weight: 462.54 : 18.02

Ref: ST-EA-CP-H9119