CAS 83881-08-7

Pregna-1,4-diene-3,20-dione,21-chloro-9,11-epoxy-17-hydroxy-16-methyl-, (9b,11b,16a)-

Description:

Pregna-1,4-diene-3,20-dione,21-chloro-9,11-epoxy-17-hydroxy-16-methyl-, commonly referred to by its CAS number 83881-08-7, is a synthetic steroid compound that exhibits characteristics typical of corticosteroids. This compound features a complex steroid structure, including a diene system and multiple functional groups such as a chloro substituent, an epoxy group, and a hydroxyl group. These structural elements contribute to its biological activity, particularly in modulating inflammatory responses and immune functions. The presence of the epoxy group suggests potential reactivity, which may influence its pharmacological properties. Additionally, the compound's stereochemistry, indicated by the specific configuration at various carbon centers, plays a crucial role in its interaction with biological targets, such as steroid receptors. Overall, this compound is of interest in medicinal chemistry and pharmacology, particularly for its potential therapeutic applications in treating conditions related to inflammation and immune dysregulation.

Formula: C₂₂H₂₇ClO₄

Synonyms:

• 21-Chloro-9-Beta,11-Beta-Epoxy-17-Hydroxy-16-Alpha-Methylpregna-1,4-Diene-3,20-Dione

Mometasone Furoate EP Impurity Q

CAS: 83881-08-7

Formula: C₂₂H₂₇ClO₄

Color and Shape: White To Off-White Solid

Molecular weight: 390.90

Ref: 4Z-M-1416

21-Chloro-9,11β-epoxy-17-hydroxy-16α-methyl-9β-pregna-1,4-diene-3,20-dione

CAS: 83881-08-7

Color and Shape: Neat

Ref: 86-MM1272.16

17α-Hydroxy-21-chloro-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione

CAS: 83881-08-7

Impurity Mometasone Impurity Q
Applications An intermediate in the synthesis of deuterated Mometason Furoate, a topical corticosteroid intermediate of used as an anti-inflammatory.
References Shapiro, E.L., et al.: J. Med. Chem., 30, 1581 (1987), Graft, D., et al.: J. Allergy Clin. Immunol., 98, 724 (1996)

Formula: C₂₂H₂₇ClO₄

Color and Shape: White To Off-White

Molecular weight: 390.90

Ref: TR-H915450

17a-Hydroxy-21-chloro-9b,11b-epoxy-16a-methylpregna-1,4-diene-3,20-dione-d5

Controlled Product

CAS: 83881-08-7

Applications 17α-Hydroxy-21-chloro-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione-d5 is an intermediate in synthesizing Mometasone-d5 (M489997), an Isotope labelled analogue of Mometasone (M489995), a potent topical corticosteroid. Mometasone has potent antiinflammatory activity and is used in the treatment of dermatological disorders.
References Schulz, M. et al.: Pharm. Zeit., 139, 28 (1994); Prakash, A. et al.: Drugs, 55, 145 (1998);

Formula: C₂₂H₂₂D₅ClO₄

Color and Shape: White

Molecular weight: 395.93

Ref: TR-H915452

Mometasone Furoate EP Impurity Q

CAS: 83881-08-7

Formula: C₂₂H₂₇ClO₄

Molecular weight: 390.9

Ref: ST-EA-CP-M248008