CAS 83881-51-0

Cetirizine

Description:

Cetirizine is an antihistamine commonly used to alleviate allergy symptoms such as sneezing, runny nose, and itchy eyes. It is classified as a second-generation antihistamine, which means it is less likely to cause sedation compared to first-generation antihistamines. Cetirizine works by selectively inhibiting the H1 histamine receptor, thereby reducing the effects of histamine in the body. Its chemical formula is C21H25ClN2O3S, and it has a molecular weight of approximately 388.96 g/mol. Cetirizine is typically administered in oral form and is known for its relatively long duration of action, making it effective for once-daily dosing. The substance is generally well-tolerated, although some individuals may experience side effects such as drowsiness, dry mouth, or gastrointestinal disturbances. Cetirizine is also used in the management of chronic urticaria (hives) and is available in various formulations, including tablets, syrup, and chewable forms. Its safety profile and efficacy make it a popular choice for treating allergic conditions.

Formula: C₂₁H₂₅ClN₂O₃

InChI: InChI=1/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)

InChI key: InChIKey=ZKLPARSLTMPFCP-UHFFFAOYSA-N

SMILES: C(N1CCN(CCOCC(O)=O)CC1)(C2=CC=C(Cl)C=C2)C3=CC=CC=C3

Synonyms:

• 2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid
• Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
• Acetic acid, [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
• 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid
• Cetirizine
• (±)-Cetirizine
• (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)aceticacid
• Zirtek
• Zyrlex
• (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-aceticaci
• Cetirizine Hydrochloride BP
• vidix
• CERTIRIZINE 2HCL
• Cetrizinehydrochloride
• 2-[2-[4-(4-Chlorobenzhydryl)-1-piperazinyl]ethoxy]acetic acid
• (2-(4-[(4-CHLORO-PHENYL)-PHENYL-METHYL]-PIPERAZIN-1-YL)-ETHOXY)-ACETIC ACID
• Reactine
• 2-[4-(4-Chlorobenzhydryl)-1-piperazinyl]ethoxyacetic acid
• Cetirizine (Cetrizine) Di HCl
• Formistin
• CETIRIZINE IMPURITY A(RS)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE EPC(CRM STANDARD)
• (RS)-2-[2-[4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride

Cetirizine Dihydrochloride

CAS: 83881-51-0, 83881-52-1

Formula: C₂₁H₂₅ClN₂O₃·2HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 461.81

Ref: 3B-C2316

2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrichloride

CAS: 83881-51-0

Formula: C₂₁H₂₅ClN₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 388.8878

Ref: IN-DA019CL1

2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid

CAS: 83881-51-0

2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid

Purity: 98%

Molecular weight: 388.9g/mol

Ref: 54-OR1059435

Cetirizine

CAS: 83881-51-0

Cetirizine is a non-sedating h1 antagonist that is used to treat allergic rhinitis and other allergic conditions. Cetirizine has been shown to produce statistically significant reductions in eosinophil cationic protein (ECP) in experimental models of allergic inflammation. The clinical significance of this finding remains unclear, but the results suggest that cetirizine may have anti-inflammatory effects. Cetirizine is metabolized by cytochrome P450 enzymes, including CYP3A4, which can lead to drug interactions with other pharmaceuticals. Low doses of cetirizine were found to inhibit 5-ht2 receptors in rats, which may be responsible for its sedative effects. Cetirizine was also found to be an effective wastewater treatment agent because it inhibits the growth of bacteria such as Escherichia coli and Pseudomonas aeruginosa.

Formula: C₂₁H₂₅ClN₂O₃

Purity: Min. 95%

Molecular weight: 388.89 g/mol

Ref: 3D-IDA88151

Levocetirizine Impurity 20

CAS: 83881-51-0

Formula: C₂₁H₂₅ClN₂O₃

Molecular weight: 388.89

Ref: ST-EA-CP-L15038