CAS 839712-12-8

Cariprazine

Description:

Cariprazine is an atypical antipsychotic medication primarily used in the treatment of schizophrenia and bipolar disorder. It functions as a partial agonist at dopamine D2 and D3 receptors, which contributes to its therapeutic effects while minimizing the risk of extrapyramidal symptoms commonly associated with other antipsychotics. Additionally, Cariprazine has a high affinity for serotonin receptors, particularly 5-HT1A and 5-HT2A, which may enhance its efficacy in mood stabilization. The substance exhibits a long half-life, allowing for once-daily dosing, and is metabolized primarily by the liver through cytochrome P450 enzymes. Its pharmacokinetic profile supports a gradual onset of action, making it suitable for long-term management of psychiatric conditions. Common side effects may include insomnia, akathisia, and gastrointestinal disturbances. As with any medication, careful monitoring is essential to optimize therapeutic outcomes and minimize adverse effects. Overall, Cariprazine represents a significant advancement in the pharmacological management of complex psychiatric disorders.

Formula: C₂₁H₃₂Cl₂N₄O

InChI: InChI=1/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)/t16-,17-

InChI key: InChIKey=KPWSJANDNDDRMB-QAQDUYKDNA-N

SMILES: ClC1=C(N2CCN(CC[C@H]3CC[C@H](NC(N(C)C)=O)CC3)CC2)C=CC=C1Cl

Synonyms:

• Cariprazine
• N′-[trans-4-[2-[4-(2,3-Dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-dimethylurea
• Rgh 188
• Vraylar
• [trans-4-[[2-[4-(2,3-Dichlorophenyl)piperazin-1-yl]ethyl]carbamoyl]cyclohexan-1-yl]-N,N-dimethylamine
• Urea, N′-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-dimethyl-

N'-[trans-4-[2-[4-(2,3-Dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-dimethylurea

CAS: 839712-12-8

Formula: C₂₁H₃₂Cl₂N₄O

Purity: 98%

Color and Shape: Solid

Molecular weight: 427.4110

Ref: IN-DA00G3NZ

Cariprazine

CAS: 839712-12-8

Cariprazine

Purity: ≥98%

Molecular weight: 427.41g/mol

Ref: 54-BUP04302

Cariprazine

CAS: 839712-12-8

Color and Shape: Neat

Ref: 86-MM3927.00

Cariprazine

CAS: 839712-12-8

Cariprazine (RGH-188) is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate

Formula: C₂₁H₃₂Cl₂N₄O

Purity: 99.68% - 99.87%

Color and Shape: Solid

Molecular weight: 427.41

Ref: TM-T4577

Cariprazine

CAS: 839712-12-8

Applications Cariprazine is an orally active D2/D3 dopamine receptor antagonist (1,2,3). Cariprazine is an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression.
References (1) Gruender, G.: Curr. Opin. Invest. Drugs, 11, 823 (2010)(2) Seneca, N. et al.: Psychopharmacology, 218, 579 (2011)(3) Kiss, B. et al.: J. Pharmacol. Exp. Therap., 333, 328 (2010)

Formula: C₂₁H₃₂Cl₂N₄O

Color and Shape: Off-White

Molecular weight: 427.41

Ref: TR-C183490

Cariprazine

CAS: 839712-12-8

Purity: 98%

Molecular weight: 427.410003662109

Ref: 10-F799842

Cariprazine

CAS: 839712-12-8

Partial agonist of D2 and D3 dopamine receptors; anti-psychotic

Formula: C₂₁H₃₂Cl₂N₄O

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 427.41 g/mol

Ref: 3D-FC64969