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CAS 839712-12-8

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Cariprazine

Description:
Cariprazine is an atypical antipsychotic medication primarily used in the treatment of schizophrenia and bipolar disorder. It functions as a partial agonist at dopamine D2 and D3 receptors, which contributes to its therapeutic effects while minimizing the risk of extrapyramidal symptoms commonly associated with other antipsychotics. Additionally, Cariprazine has a high affinity for serotonin receptors, particularly 5-HT1A and 5-HT2A, which may enhance its efficacy in mood stabilization. The substance exhibits a long half-life, allowing for once-daily dosing, and is metabolized primarily by the liver through cytochrome P450 enzymes. Its pharmacokinetic profile supports a gradual onset of action, making it suitable for long-term management of psychiatric conditions. Common side effects may include insomnia, akathisia, and gastrointestinal disturbances. As with any medication, careful monitoring is essential to optimize therapeutic outcomes and minimize adverse effects. Overall, Cariprazine represents a significant advancement in the pharmacological management of complex psychiatric disorders.
Formula:C21H32Cl2N4O
InChI:InChI=1/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)/t16-,17-
InChI key:InChIKey=KPWSJANDNDDRMB-QAQDUYKDNA-N
SMILES:ClC1=C(N2CCN(CC[C@H]3CC[C@H](NC(N(C)C)=O)CC3)CC2)C=CC=C1Cl
Synonyms:
  • Cariprazine
  • N′-[trans-4-[2-[4-(2,3-Dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-dimethylurea
  • Rgh 188
  • Vraylar
  • [trans-4-[[2-[4-(2,3-Dichlorophenyl)piperazin-1-yl]ethyl]carbamoyl]cyclohexan-1-yl]-N,N-dimethylamine
  • Urea, N′-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-dimethyl-
Found 9 products.