CAS 84449-90-1

Raloxifene

Description:

Raloxifene is a selective estrogen receptor modulator (SERM) primarily used in the treatment and prevention of osteoporosis in postmenopausal women and for reducing the risk of invasive breast cancer. Its chemical formula is C28H27NO4S, and it features a sulfonamide group, which contributes to its biological activity. Raloxifene exhibits estrogenic effects on bone tissue, promoting bone density while antagonizing estrogen receptors in breast and uterine tissues, thereby reducing the risk of estrogen-dependent cancers. The substance is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Raloxifene is well-absorbed in the gastrointestinal tract, but its bioavailability is affected by first-pass metabolism. Common side effects may include hot flashes, leg cramps, and an increased risk of thromboembolic events. As a non-steroidal compound, Raloxifene's mechanism of action involves binding to estrogen receptors and modulating gene expression, making it a valuable therapeutic option in women's health.

Formula: C₂₈H₂₇NO₄S

InChI: InChI=1S/C28H27NO4S/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29/h4-13,18,30-31H,1-3,14-17H2

InChI key: InChIKey=GZUITABIAKMVPG-UHFFFAOYSA-N

SMILES: C(=O)(C1=C(SC=2C1=CC=C(O)C2)C3=CC=C(O)C=C3)C4=CC=C(OCCN5CCCCC5)C=C4

Synonyms:

• [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone
• Methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-
• Raloxifene
• Keoxifene
• LY 139481

RALOXIFENE

CAS: 84449-90-1

RALOXIFENE

Purity: 97%

Molecular weight: 473.5899963

Ref: 10-F794023

Raloxifene

CAS: 84449-90-1

Raloxifene

Formula: C₂₈H₂₇NO₄S

Purity: 99.5%

Molecular weight: 473.58

Ref: 54-BUP20466

Raloxifene

Controlled Product

CAS: 84449-90-1

Formula: C₂₈H₂₇NO₄S

Color and Shape: Neat

Molecular weight: 473.58

Ref: 04-C16806200

Raloxifene

Controlled Product

CAS: 84449-90-1

Applications Raloxifene is a nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.
References Jone, C.D., et al.: J. Med. Chem., 27, 1057 (1984); Buelke-Sam, J., et al.: Reprod. Toxicol., 12, 217 (1998)

Formula: C₂₈H₂₇NO₄S

Color and Shape: Neat

Molecular weight: 473.58

Ref: TR-R099995

Raloxifene

CAS: 84449-90-1

Raloxifene (LY139481) is an estrogen receptor modulator exhibiting estrogen agonist and antagonist activity at different sites, with antiviral activity.

Formula: C₂₈H₂₇NO₄S

Purity: 99.39% - 99.87%

Color and Shape: Solid

Molecular weight: 473.58

Ref: TM-T20419

Raloxifene

CAS: 84449-90-1

Formula: C₂₈H₂₇NO₄S

Color and Shape: Solid

Molecular weight: 473.6

Ref: BE-BePure-25426

Raloxifene

CAS: 84449-90-1

Formula: C₂₈H₂₇NO₄S

Molecular weight: 473.54

Ref: ST-EA-CP-R2000