CAS 84687-43-4
:Astragaloside IV
Description:
Astragaloside IV is a natural compound primarily derived from the root of Astragalus membranaceus, a traditional medicinal herb. It belongs to the class of saponins, which are glycosides with a steroid or triterpenoid aglycone. This compound is known for its potential pharmacological properties, including immunomodulatory, anti-inflammatory, and antioxidant effects. Astragaloside IV has been studied for its ability to enhance immune function and protect against oxidative stress, making it of interest in various therapeutic applications. The substance is typically characterized by its solubility in water and organic solvents, and it exhibits a relatively low toxicity profile. Its molecular structure features a sugar moiety attached to a triterpenoid backbone, which contributes to its biological activity. Research continues to explore its mechanisms of action and potential benefits in health and disease management, particularly in the context of chronic conditions and aging.
Formula:C41H68O14
InChI:InChI=1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33-,34+,37+,38-,39+,40-,41+/m0/s1
InChI key:InChIKey=QMNWISYXSJWHRY-YLNUDOOFSA-N
SMILES:C[C@]12[C@]3([C@]4([C@]5(C4)[C@@]([C@@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)C3)(C(C)(C)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@H](O)CO7)CC5)[H])CC[C@]1(C)[C@]([C@@H](O)C2)([C@]8(C)O[C@H](C(C)(C)O)CC8)[H])[H]
Synonyms:- (3β,6α,16β,20R,24S)-20,24-Epoxy-16,25-dihydroxy-3-(β-<span class="text-smallcaps">D</smallcap>-xylopyranosyloxy)-9,19-cyclolanostan-6-yl β-<smallcap>D</span>-glucopyranoside
- (5xi,6beta,8xi,9xi,16alpha,20R,24S)-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy)-20,24-epoxy-9,19-cyclolanostan-6-yl beta-D-glucopyranoside
- 1H,19H-Cyclopropa[9,10]cyclopenta[a]phenanthrene, β-<span class="text-smallcaps">D</span>-glucopyranoside deriv.
- 9,19-Cyclolanostane, β-<span class="text-smallcaps">D</span>-glucopyranoside deriv.
- Astrasieversianin XIV
- Astraversianin XIV
- Cyclosieversioside F
- Cyclosiversioside F
- astragalosideⅣ
- beta-D-Glucopyranoside, (3beta,6alpha,16beta,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl
- β-<span class="text-smallcaps">D</smallcap>-Glucopyranoside, (3β,6α,16β,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-(β-<smallcap>D</span>-xylopyranosyloxy)-9,19-cyclolanostan-6-yl
- 9,19-Cyclolanostane, β-D-glucopyranoside deriv.
- (3β,6α,16β,20R,24S)-20,24-Epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl β-D-glucopyranoside
- β-D-Glucopyranoside, (3β,6α,16β,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl
- Astragaloside IV
- See more synonyms
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Astragaloside IV
CAS:Formula:C41H68O14Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:784.98Astragaloside IV
CAS:Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoiFormula:C41H68O14Color and Shape:Off-White PowderMolecular weight:784.46091Astragaloside IV
CAS:Formula:C41H68O14Color and Shape:White To Off-White SolidMolecular weight:784.98Astragaloside IV
CAS:Astragaloside IVFormula:C41H68O14Purity:98%Color and Shape:SolidMolecular weight:784.97Astragaloside IV
CAS:Formula:C41H68O14Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:784.97Astragaloside IV (Standard)
CAS:Astragaloside IV (Standard) is a reference standard for research and analysis in studies involving Astragaloside IV. Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.Formula:C41H68O14Molecular weight:784.97Astragaloside IV
CAS:Astragaloside IV, a saponin isolated from Astragalus membranaceus, has been shown to protect the myocardium against ischemia/reperfusion injury, it also has beneficial effect in H/R-induced injury may be related to normalization of SR Ca2+ pump expression and, thus, it may prevent the depression in SR Ca2+ handling.Formula:C41H68O14Purity:95%~99%Color and Shape:White powderMolecular weight:784.981Astragaloside IV
CAS:Controlled ProductApplications Astragaloside IV has cardiovascular protective effects, protecting the vascular endothelial cells. In addition it is attributed to have anti0inflammatory and anti-virus effects as well. This is due to its scavenging ability of oxygen free radicals, regulation of mineral homeostasis and antioxidative effects.
References Liu, S. et al.: J. Chinese Pharm. Sci., 22, 222 (2013);Formula:C41H68O14Color and Shape:NeatMolecular weight:784.97Astragaloside IV
CAS:Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.Formula:C41H68O14Purity:99% - 99.84%Color and Shape:SolidMolecular weight:784.9702Astragaloside IV
CAS:Natural glycosideFormula:C41H68O14Purity:≥ 90.0 % (HPLC)Color and Shape:PowderMolecular weight:784.99Astragaloside IV
CAS:(2R,3R,4S,5S,6R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-Hydroxy-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-9-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthren-7-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triolFormula:C41H68O14Purity:98%Molecular weight:784.97Astragaloside IV
CAS:Astragaloside IV is a bioactive compound, which is a primary saponin derived from the roots of Astragalus membranaceus, a plant commonly used in traditional Chinese medicine. This compound functions primarily through modulating cellular signaling pathways, exhibiting its effects via antioxidant, anti-inflammatory, and immunomodulatory actions.Formula:C41H68O14Purity:Min. 95%Color and Shape:PowderMolecular weight:784.97 g/molRef: 3D-MA08288
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