CAS 847925-91-1

Ro 4929097

Description:

Ro 4929097, with the CAS number 847925-91-1, is a small molecule that acts as a potent and selective inhibitor of the Notch signaling pathway. This compound is primarily studied for its potential therapeutic applications in cancer treatment, particularly in tumors where aberrant Notch signaling contributes to tumorigenesis. Ro 4929097 exhibits characteristics typical of small organic compounds, including a defined molecular structure that allows it to interact specifically with the Notch receptor. Its mechanism of action involves blocking the cleavage of the Notch receptor, thereby inhibiting the downstream signaling that promotes cell proliferation and survival. In preclinical studies, Ro 4929097 has shown promise in reducing tumor growth and enhancing the efficacy of other anticancer agents. However, like many investigational drugs, its safety profile and full therapeutic potential are still under evaluation in clinical trials. Overall, Ro 4929097 represents a significant focus in the field of targeted cancer therapies, particularly in the context of Notch-related malignancies.

Formula: C₂₂H₂₀F₅N₃O₃

InChI: InChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1

InChI key: InChIKey=OJPLJFIFUQPSJR-INIZCTEOSA-N

SMILES: N(C(C(C(NCC(C(F)(F)F)(F)F)=O)(C)C)=O)[C@H]1C=2C(C=3C(NC1=O)=CC=CC3)=CC=CC2

Synonyms:

• N1-[(7S)-6,7-Dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)propanediamide
• Propanediamide, N-[(7S)-6,7-dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N′-(2,2,3,3,3-pentafluoropropyl)-
• RO4929097
• Ro 4929097
• Propanediamide, N1-[(7S)-6,7-dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)-
• RO4929097;RO-4929097;RO 4929097
• N1-[(7S)-6,7-Dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropr
• N1-[(7S)-6,7-Dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)propanediamide Ro 4929097
• RO4929097, >=98%
• Ro 4929097 N1-[(7S)-6,7-Dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)propanediamide
• CS-14
• RG-4733
• RO4929097 (RG-4733)
• RO 4929097, 98%, a γ secretase inhibitor
• RO-4929097;RO 4929097

N1-[(7S)-6,7-Dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)propanediamide

CAS: 847925-91-1

Formula: C₂₂H₂₀F₅N₃O₃

Purity: %

Color and Shape: Solid

Molecular weight: 469.4045

Ref: IN-DA003ACA

(S)-2,2-Dimethyl-N1-(6-Oxo-6,7-Dihydro-5H-Dibenzo[B,D]Azepin-7-Yl)-N3-(2,2,3,3,3-Pentafluoropropyl)Malonamide

CAS: 847925-91-1

(S)-2,2-Dimethyl-N1-(6-Oxo-6,7-Dihydro-5H-Dibenzo[B,D]Azepin-7-Yl)-N3-(2,2,3,3,3-Pentafluoropropyl)Malonamide

Purity: 98+%

Molecular weight: 469.4g/mol

Ref: 54-PC108700

RO4929097

CAS: 847925-91-1

RO4929097

Purity: ≥95%

Molecular weight: 469.4g/mol

Ref: 54-BUP05485

RO4929097

CAS: 847925-91-1

RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).

Formula: C₂₂H₂₀F₅N₃O₃

Purity: 98.5% - 99.51%

Color and Shape: Solid

Molecular weight: 469.4

Ref: TM-T6274

Ro492097

CAS: 847925-91-1

Inhibitor of γ-secretase and Notch signalling

Formula: C₂₂H₂₀F₅N₃O₃

Purity: Min. 95%

Molecular weight: 469.4 g/mol

Ref: 3D-FR65150