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CAS 847925-91-1

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Ro 4929097

Description:
Ro 4929097, with the CAS number 847925-91-1, is a small molecule that acts as a potent and selective inhibitor of the Notch signaling pathway. This compound is primarily studied for its potential therapeutic applications in cancer treatment, particularly in tumors where aberrant Notch signaling contributes to tumorigenesis. Ro 4929097 exhibits characteristics typical of small organic compounds, including a defined molecular structure that allows it to interact specifically with the Notch receptor. Its mechanism of action involves blocking the cleavage of the Notch receptor, thereby inhibiting the downstream signaling that promotes cell proliferation and survival. In preclinical studies, Ro 4929097 has shown promise in reducing tumor growth and enhancing the efficacy of other anticancer agents. However, like many investigational drugs, its safety profile and full therapeutic potential are still under evaluation in clinical trials. Overall, Ro 4929097 represents a significant focus in the field of targeted cancer therapies, particularly in the context of Notch-related malignancies.
Formula:C22H20F5N3O3
InChI:InChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1
InChI key:InChIKey=OJPLJFIFUQPSJR-INIZCTEOSA-N
SMILES:N(C(C(C(NCC(C(F)(F)F)(F)F)=O)(C)C)=O)[C@H]1C=2C(C=3C(NC1=O)=CC=CC3)=CC=CC2
Synonyms:
  • N1-[(7S)-6,7-Dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)propanediamide
  • Propanediamide, N-[(7S)-6,7-dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N′-(2,2,3,3,3-pentafluoropropyl)-
  • RO4929097
  • Ro 4929097
  • Propanediamide, N1-[(7S)-6,7-dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)-
  • RO4929097;RO-4929097;RO 4929097
  • N1-[(7S)-6,7-Dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropr
  • N1-[(7S)-6,7-Dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)propanediamide Ro 4929097
  • RO4929097, >=98%
  • Ro 4929097 N1-[(7S)-6,7-Dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)propanediamide
  • See more synonyms
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