CAS 847949-49-9

4-(3-chloro-4-fluoro-anilino)-6-(3-morpholinopropoxy)quinazolin-7-ol

Description:

4-(3-chloro-4-fluoro-anilino)-6-(3-morpholinopropoxy)quinazolin-7-ol is a synthetic organic compound characterized by its complex structure, which includes a quinazoline core substituted with various functional groups. The presence of a chloro and a fluoro group on the aniline moiety contributes to its potential biological activity, possibly enhancing its interaction with specific targets in biological systems. The morpholinopropoxy side chain may influence the compound's solubility and permeability, which are critical for pharmacological properties. This compound is likely to exhibit properties typical of quinazoline derivatives, such as potential anti-cancer or anti-inflammatory activities, although specific biological effects would depend on further empirical studies. Its molecular structure suggests it may engage in hydrogen bonding and other intermolecular interactions, which could affect its stability and reactivity. As with many synthetic compounds, safety and handling precautions are essential due to potential toxicity or environmental impact.

Formula: C₂₁H₂₂ClFN₄O₃

InChI: InChI=1/C21H22ClFN4O3/c22-16-10-14(2-3-17(16)23)26-21-15-11-20(19(28)12-18(15)24-13-25-21)30-7-1-4-27-5-8-29-9-6-27/h2-3,10-13,28H,1,4-9H2,(H,24,25,26)

SMILES: C(CN1CCOCC1)COc1cc2c(cc1O)ncnc2Nc1ccc(c(c1)Cl)F

7-Quinazolinol,4-[(3-chloro-4-fluorophenyl)amino]-6-[3-(4-morpholinyl)propoxy]-

CAS: 847949-49-9

Formula: C₂₁H₂₂ClFN₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 432.8758

Ref: IN-DA004OK1

O-Desmethyl gefitinib

CAS: 847949-49-9

O-Desmethyl gefitinib is an active EGFR inhibitor (IC50: 36 nM), a metabolite of Gefitinib, formed by CYP2D6.

Formula: C₂₁H₂₂ClFN₄O₃

Purity: 97.17%

Color and Shape: Solid

Molecular weight: 432.88

Ref: TM-T16369

O-Desmethyl Gefitinib

CAS: 847949-49-9

Formula: C₂₁H₂₂ClFN₄O₃

Color and Shape: Pale Yellow Solid

Molecular weight: 432.88

Ref: 4Z-G-233

O-Desmethyl gefitinib

CAS: 847949-49-9

O-Desmethyl gefitinib

Purity: ≥95%

Molecular weight: 432.88g/mol

Ref: 54-BUP05403

O-Desmethyl Gefitinib-d6

CAS: 847949-49-9

Formula: C₂₁H₁₆ClFN₄O₃D₆

Color and Shape: Pale Yellow Solid

Molecular weight: 438.92

Ref: 4Z-G-2324

O-Desmethyl gefitinib

CAS: 847949-49-9

Purity: 98%

Molecular weight: 432.880004882813

Ref: 10-F601011

4-[(3-Chloro-4-fluorophenyl)amino]-6-[3-(morpholin-4-yl)propoxy]quinazolin-7-ol (O-Demethylgefitinib)

CAS: 847949-49-9

Color and Shape: Neat

Ref: 86-MM3563.10

O-Desmethyl Gefitinib

Controlled Product

CAS: 847949-49-9

Stability Hygroscopic
Applications A major metabolite of Gefitinib.
References Ranson, M., et al.: J. Clin. Oncology, 20, 2240 (2002), Mendelsohn, J., et al.: J. Clin. Oncology, 21, 2787 (2003), McKillop, D., et al.: Xenobiotica, 10, 917 (2004),

Formula: C₂₁H₂₂ClFN₄O₃

Color and Shape: Yellow

Molecular weight: 432.88

Ref: TR-D291680

O-Desmethyl gefitinib

CAS: 847949-49-9

Gefitinib is a small-molecule drug that is used for the treatment of non-small cell lung cancer. It is an inhibitor of the protein tyrosine kinase receptor, epidermal growth factor receptor (EGFR). Gefitinib also inhibits the activity of enzymes such as glycoprotein IIb/IIIa and serine proteases. The pharmacokinetics of gefitinib have been studied in humans and rats, with a plasma concentration–time curve observed in both species. In humans, gefitinib was found to be eliminated by hepatic metabolism and excreted mainly through urine. In rats, gefitinib was eliminated by both hepatic metabolism and renal excretion. The pharmacokinetics of gefitinib were altered in rats with liver impairment due to sorafenib or high doses of epidermal growth factor (EGF). A multivariate logistic regression model was used to study

Formula: C₂₁H₂₂ClFN₄O₃

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 432.88 g/mol

Ref: 3D-FD21274

O-Desmethyl Gefitinib-d6

Controlled Product

CAS: 847949-49-9

Formula: C₂₁D₆H₁₆ClFN₄O₃

Color and Shape: Neat

Molecular weight: 438.913

Ref: TR-D291682

O-Desmethyl Gefitinib

CAS: 847949-49-9

Formula: C₂₁H₂₂ClFN₄O₃

Molecular weight: 432.88

Ref: ST-EA-CP-G14010