CAS 847949-49-9
:4-(3-chloro-4-fluoro-anilino)-6-(3-morpholinopropoxy)quinazolin-7-ol
Description:
4-(3-chloro-4-fluoro-anilino)-6-(3-morpholinopropoxy)quinazolin-7-ol is a synthetic organic compound characterized by its complex structure, which includes a quinazoline core substituted with various functional groups. The presence of a chloro and a fluoro group on the aniline moiety contributes to its potential biological activity, possibly enhancing its interaction with specific targets in biological systems. The morpholinopropoxy side chain may influence the compound's solubility and permeability, which are critical for pharmacological properties. This compound is likely to exhibit properties typical of quinazoline derivatives, such as potential anti-cancer or anti-inflammatory activities, although specific biological effects would depend on further empirical studies. Its molecular structure suggests it may engage in hydrogen bonding and other intermolecular interactions, which could affect its stability and reactivity. As with many synthetic compounds, safety and handling precautions are essential due to potential toxicity or environmental impact.
Formula:C21H22ClFN4O3
InChI:InChI=1/C21H22ClFN4O3/c22-16-10-14(2-3-17(16)23)26-21-15-11-20(19(28)12-18(15)24-13-25-21)30-7-1-4-27-5-8-29-9-6-27/h2-3,10-13,28H,1,4-9H2,(H,24,25,26)
InChI key:IFMMYZUUCFPEHR-UHFFFAOYSA-N
SMILES:C(CN1CCOCC1)COc1cc2c(cc1O)ncnc2Nc1ccc(c(c1)Cl)F
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O-Desmethyl gefitinib
CAS:O-Desmethyl gefitinib is an active EGFR inhibitor (IC50: 36 nM), a metabolite of Gefitinib, formed by CYP2D6.Formula:C21H22ClFN4O3Purity:97.17%Color and Shape:White SolidMolecular weight:432.876O-Desmethyl gefitinib
CAS:O-Desmethyl gefitinibFormula:C21H22ClFN4O3Purity:≥95%Molecular weight:432.88O-Desmethyl Gefitinib
CAS:Formula:C21H22ClFN4O3Color and Shape:Pale Yellow SolidMolecular weight:432.88O-Desmethyl Gefitinib-d6
CAS:Formula:C21H16ClFN4O3D6Color and Shape:Pale Yellow SolidMolecular weight:438.924-[(3-Chloro-4-fluorophenyl)amino]-6-[3-(morpholin-4-yl)propoxy]quinazolin-7-ol (O-Demethylgefitinib)
CAS:Formula:C21H22ClFN4O3Color and Shape:NeatMolecular weight:432.884-((3-Chloro-4-fluorophenyl)amino)-6-(3-morpholinopropoxy)quinazolin-7-ol
CAS:Formula:C21H22ClFN4O3Purity:98%Color and Shape:SolidMolecular weight:432.8758O-Desmethyl gefitinib
CAS:4-((3-Chloro-4-fluorophenyl)amino)-6-(3-morpholinopropoxy)quinazolin-7-olFormula:C21H22ClFN4O3Purity:99%Molecular weight:432.88O-Desmethyl gefitinib
CAS:Gefitinib is a small-molecule drug that is used for the treatment of non-small cell lung cancer. It is an inhibitor of the protein tyrosine kinase receptor, epidermal growth factor receptor (EGFR). Gefitinib also inhibits the activity of enzymes such as glycoprotein IIb/IIIa and serine proteases. The pharmacokinetics of gefitinib have been studied in humans and rats, with a plasma concentration–time curve observed in both species. In humans, gefitinib was found to be eliminated by hepatic metabolism and excreted mainly through urine. In rats, gefitinib was eliminated by both hepatic metabolism and renal excretion. The pharmacokinetics of gefitinib were altered in rats with liver impairment due to sorafenib or high doses of epidermal growth factor (EGF). A multivariate logistic regression model was used to studyFormula:C21H22ClFN4O3Purity:Min. 95 Area-%Color and Shape:PowderMolecular weight:432.88 g/molO-Desmethyl Gefitinib
CAS:Controlled ProductStability Hygroscopic
Applications A major metabolite of Gefitinib.
References Ranson, M., et al.: J. Clin. Oncology, 20, 2240 (2002), Mendelsohn, J., et al.: J. Clin. Oncology, 21, 2787 (2003), McKillop, D., et al.: Xenobiotica, 10, 917 (2004),Formula:C21H22ClFN4O3Color and Shape:NeatMolecular weight:432.88O-Desmethyl gefitinib (Standard)
CAS:O-Desmethyl gefitinib (Standard) is a reference standard for research and analysis in studies involving O-Desmethyl gefitinib. O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 activity.Formula:C21H22ClFN4O3Molecular weight:432.876O-Desmethyl Gefitinib-d6
CAS:Controlled ProductFormula:C21D6H16ClFN4O3Color and Shape:NeatMolecular weight:438.913
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