CAS 848141-11-7

Alvelestat

Description:

Alvelestat, with the CAS number 848141-11-7, is a small molecule inhibitor primarily designed to target neutrophil elastase, an enzyme implicated in various inflammatory conditions, particularly in chronic obstructive pulmonary disease (COPD) and other respiratory disorders. This compound is characterized by its ability to modulate inflammatory responses by inhibiting the activity of neutrophil elastase, thereby potentially reducing tissue damage and inflammation associated with excessive neutrophil activity. Alvelestat has been investigated in clinical trials for its therapeutic efficacy and safety profile. Its chemical structure features specific functional groups that contribute to its biological activity and pharmacokinetic properties. As a therapeutic agent, it is important to consider its solubility, stability, and metabolic pathways, which influence its effectiveness and dosing regimen. Overall, Alvelestat represents a promising approach in the management of diseases characterized by neutrophil-mediated inflammation.

Formula: C25H22F3N5O4S

InChI: InChI=1S/C25H22F3N5O4S/c1-15-20(22-9-10-31-32(22)2)12-21(23(34)30-13-17-7-8-19(14-29-17)38(3,36)37)24(35)33(15)18-6-4-5-16(11-18)25(26,27)28/h4-12,14H,13H2,1-3H3,(H,30,34)

InChI key: QNQZWEGMKJBHEM-UHFFFAOYSA-N

SMILES: CC1=C(C=C(C(=O)N1C2=CC=CC(=C2)C(F)(F)F)C(=O)NCC3=NC=C(C=C3)S(=O)(=O)C)C4=CC=NN4C

ALVELESTAT

CAS: 848141-11-7

ALVELESTAT

Purity: 98%

Molecular weight: 545.539978

Ref: 10-F799853

6-Methyl-5-(1-Methyl-1H-Pyrazol-5-Yl)-N-((5-(Methylsulfonyl)Pyridin-2-Yl)Methyl)-2-Oxo-1-(3-(Trifluoromethyl)Phenyl)-1,2-Dihydropyridine-3-Carboxamide

CAS: 848141-11-7

6-Methyl-5-(1-Methyl-1H-Pyrazol-5-Yl)-N-((5-(Methylsulfonyl)Pyridin-2-Yl)Methyl)-2-Oxo-1-(3-(Trifluoromethyl)Phenyl)-1,2-Dihydropyridine-3-Carboxamide

Formula: C₂₅H₂₂F₃N₅O₄S

Purity: 99%

Molecular weight: 545.53

Ref: 54-PC108699

Alvelestat

CAS: 848141-11-7

Alvelestat

Formula: C₂₅H₂₂F₃N₅O₄S

Purity: 99.5%

Molecular weight: 545.53

Ref: 54-BUP08129

6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide

CAS: 848141-11-7

6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide

Formula: C₂₅H₂₂F₃N₅O₄S

Purity: 99% (HPLC)

Molecular weight: 545.53

Ref: IN-DG630896

Alvelestat

CAS: 848141-11-7

Alvelestat (AZD9668) is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.

Formula: C₂₅H₂₂F₃N₅O₄S

Purity: 98% - >99.99%

Color and Shape: White Solid

Molecular weight: 545.533

Ref: TM-T3107

Avelestat

Controlled Product

CAS: 848141-11-7

Applications Avelstat inhibits plasma neutrophil elastase (NE) activity in zymosan-stimulated whole blood, and also inhibits NE activity on the surface of stimulated polymorphonuclear cells and in the supernatant of primed, stimulated cells.
References Stevens, T., et al.: J. Pharmacol. Exp. Ther., 339, 313 (2011)

Formula: C₂₅H₂₂F₃N₅O₄S

Color and Shape: Neat

Molecular weight: 545.53

Ref: TR-A794660