CAS 848861-65-4

FMOC-GLY-(DMB)GLY-OH

Description:

FMOC-GLY-(DMB)GLY-OH, with the CAS number 848861-65-4, is a chemical compound commonly used in peptide synthesis and research. It features a protected glycine residue, where FMOC (9-fluorenylmethoxycarbonyl) serves as a protective group for the amino functionality, allowing for selective reactions during peptide assembly. The presence of DMB (dimethylbenzyl) indicates an additional modification that can enhance the compound's stability and solubility. This compound is typically utilized in solid-phase peptide synthesis, where the protection and deprotection of functional groups are crucial for the successful formation of peptides. Its structure allows for the introduction of various amino acids in a controlled manner, facilitating the synthesis of complex peptides. The compound is generally stable under standard laboratory conditions but may require specific handling to maintain its integrity during synthesis processes. Overall, FMOC-GLY-(DMB)GLY-OH is an important tool in the field of organic chemistry and biochemistry, particularly in the development of peptide-based therapeutics and research applications.

Formula: C₂₈H₂₈N₂O₇

Fmoc-Gly-(Dmb)Gly-OH

CAS: 848861-65-4

Introduction of the Dmb-moiety disrupts aggregated sequences during Fmoc-SPPS as efficiently as a pseudoproline residue. Dmb dipeptides couple smoothly, as, contrary to Hmb dipeptides, they cannot form oxazepinones. Dmb is removed during the final TFA cleavage in the presence of scavengers.

Formula: C₂₈H₂₈N₂O₇

Purity: 98.83%

Color and Shape: White

Molecular weight: 504.54

Ref: 01-4062764

Fmoc-Gly-(Dmb)Gly-OH

CAS: 848861-65-4

Formula: C₂₈H₂₈N₂O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 504.5311

Ref: IN-DA00G3IR

Fmoc-Gly-(Dmb)Gly-OH

CAS: 848861-65-4

Fmoc-Gly-(Dmb)Gly-OH

Purity: ≥95%

Color and Shape: Solid

Molecular weight: 504.53g/mol

Ref: 54-OR36480

Fmoc-Gly-(Dmb)Gly-OH

CAS: 848861-65-4

Fmoc-Gly-(Dmb)Gly-OH is a synthetic peptide that modulates cellular activity. It encompasses a wide range of activities, such as cancer cell growth and restenosis, fibroid tumors and bowel disease. Fmoc-Gly-(Dmb)Gly-OH has been shown to be an effective chemotherapeutic agent in the treatment of age-related macular degeneration and retinopathy. It also inhibits inflammatory bowel disease and infarction by restricting the production of inflammatory cytokines, such as TNFα, IL1β, and IL6. Fmoc-Gly-(Dmb)Gly-OH can be used to treat endometriosis by inhibiting angiogenesis in the uterus.

Formula: C₂₈H₂₈N₂O₇

Purity: Min. 95%

Molecular weight: 504.53 g/mol

Ref: 3D-FF50732