CAS 850140-72-6: Afatinib
Description:Afatinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of non-small cell lung cancer (NSCLC) that harbors specific mutations in the epidermal growth factor receptor (EGFR) gene. It is characterized by its ability to irreversibly bind to the EGFR and other members of the ErbB family of receptors, thereby inhibiting their signaling pathways that promote cell proliferation and survival. The chemical formula of Afatinib is C24H25ClFN5O3, and it features a complex structure that includes a chloro-substituted phenyl ring and a piperazine moiety. Afatinib is administered orally and is known for its potential side effects, which may include diarrhea, rash, and stomatitis. Its pharmacokinetics indicate that it has a relatively long half-life, allowing for once-daily dosing. The drug is classified as an antineoplastic agent and is part of targeted therapy, representing a significant advancement in personalized medicine for patients with specific genetic profiles in their tumors.
Formula:C24H25ClFN5O3
InChI:InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
InChI key:InChIKey=ULXXDDBFHOBEHA-CWDCEQMOSA-N
SMILES:O=C(C=CCN(C)C)NC1=CC=2C(=NC=NC2NC3=CC=C(F)C(Cl)=C3)C=C1OC4COCC4
- Synonyms:
- (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
- (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
- (E)-N-(7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
- (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-dime
- 2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydro-3-furanyl)oxy)-6-quinazolinyl)-4-(dimethylamino)-
- 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-
- Afatinib
- Bibw 2992
- Bibw2992
- Gilotrif
- See more synonyms
- Giotrif
- Tovok
