CAS 850140-72-6

Afatinib

Description:

Afatinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of non-small cell lung cancer (NSCLC) that harbors specific mutations in the epidermal growth factor receptor (EGFR) gene. It is characterized by its ability to irreversibly bind to the EGFR and other members of the ErbB family of receptors, thereby inhibiting their signaling pathways that promote cell proliferation and survival. The chemical formula of Afatinib is C24H25ClFN5O3, and it features a complex structure that includes a chloro-substituted phenyl ring and a piperazine moiety. Afatinib is administered orally and is known for its potential side effects, which may include diarrhea, rash, and stomatitis. Its pharmacokinetics indicate that it has a relatively long half-life, allowing for once-daily dosing. The drug is classified as an antineoplastic agent and is part of targeted therapy, representing a significant advancement in personalized medicine for patients with specific genetic profiles in their tumors.

Formula: C₂₄H₂₅ClFN₅O₃

InChI: InChI=1/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+

InChI key: InChIKey=ULXXDDBFHOBEHA-CWDCEQMOSA-N

SMILES: N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

Synonyms:

• (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
• (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
• (E)-N-(7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
• (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-dime
• 2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydro-3-furanyl)oxy)-6-quinazolinyl)-4-(dimethylamino)-
• 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-
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Afatinib

CAS: 850140-72-6

Formula: C₂₄H₂₅ClFN₅O₃

Purity: >97.0%(HPLC)(N)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 485.94

Ref: 3B-A2870

Afatinib (BIBW 2992)

CAS: 850140-72-6

Formula: C₂₄H₂₅ClFN₅O₃

Color and Shape: White To Off-White Solid

Molecular weight: 485.95

Ref: 4Z-A-111001

Afatinib

CAS: 850140-72-6

Afatinib

Purity: ≥95%

Molecular weight: 485.94g/mol

Ref: 54-BUP15589

Afatinib

CAS: 850140-72-6

Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.

Formula: C₂₄H₂₅ClFN₅O₃

Purity: 98.56% - 99.9%

Color and Shape: Off-White Solid

Molecular weight: 485.94

Ref: TM-T21312

Afatinib-d4

CAS: 850140-72-6

Formula: C₂₄H₂₁ClFN₅O₃D₄

Molecular weight: 489.97

Ref: 4Z-A-111002

Afatinib

CAS: 850140-72-6

Afatinib

Formula: C₂₄H₂₅ClFN₅O₃

Purity: By hplc: >99% (Typical Value in Batch COA)

Color and Shape: white to off-white solid

Molecular weight: 485.94g/mol

Ref: 54-BIFK0010

Afatinib, Free Base

CAS: 850140-72-6

Purity: 99.0%

Color and Shape: Solid, No data available.

Molecular weight: 485.94000244140625

Ref: 10-F050665

Afatinib

CAS: 850140-72-6

Applications An aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
References Nakao, K., et al.: Sci. Rep., 9, 18202 92019); Ebert, K, PLoS One, 14, 0223225 (2019)

Formula: C₂₄H₂₅ClFN₅O₃

Color and Shape: Neat

Molecular weight: 485.94

Ref: TR-A355300

Afatinib - Bio-X ™

CAS: 850140-72-6

Afatinib is a small molecule that inhibits the activity of cellular kinases that are involved in the progression of cancer. It is an Irreversible inhibitor of three members of the ErbB family. This molecule binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling which inhibits cellular growth and promotes apoptosis. It has been researched for the treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer and colorectal cancer.

Formula: C₂₄H₂₅ClFN₅O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 485.94 g/mol

Ref: 3D-BA164141

Afatinib-d4

Controlled Product

CAS: 850140-72-6

Formula: C₂₄D₄H₂₁ClFN₅O₃

Color and Shape: Neat

Molecular weight: 489.963

Ref: TR-A355302

Afatinib

CAS: 850140-72-6

Irreversible blocker of three members of the ErbB family (ErbB1, ErbB2/HER2, and ErbB4) with IC50 in nanomolar range. The compound binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling, inhibits cellular growth and promotes apoptosis. Afatinib has been used for the treatment of tyrosine kinase inhibitor-resistant tumours with mutations in ErbB genes, especially for deletions in exon 19 and single nucleotide substitutions in exon 21. It has been used for treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer, colorectal cancer, etc.

Formula: C₂₄H₂₅ClFN₅O₃

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 485.94 g/mol

Ref: 3D-FC17230