CAS 850140-72-6
:Afatinib
Description:
Afatinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of non-small cell lung cancer (NSCLC) that harbors specific mutations in the epidermal growth factor receptor (EGFR) gene. It is characterized by its ability to irreversibly bind to the EGFR and other members of the ErbB family of receptors, thereby inhibiting their signaling pathways that promote cell proliferation and survival. The chemical formula of Afatinib is C24H25ClFN5O3, and it features a complex structure that includes a chloro-substituted phenyl ring and a piperazine moiety. Afatinib is administered orally and is known for its potential side effects, which may include diarrhea, rash, and stomatitis. Its pharmacokinetics indicate that it has a relatively long half-life, allowing for once-daily dosing. The drug is classified as an antineoplastic agent and is part of targeted therapy, representing a significant advancement in personalized medicine for patients with specific genetic profiles in their tumors.
Formula:C24H25ClFN5O3
InChI:InChI=1/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+
InChI key:InChIKey=ULXXDDBFHOBEHA-CWDCEQMOSA-N
SMILES:N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4
Synonyms:- (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
- (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
- (E)-N-(7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
- (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-dime
- 2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydro-3-furanyl)oxy)-6-quinazolinyl)-4-(dimethylamino)-
- 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-
- Afatinib
- Bibw 2992
- Bibw2992
- Gilotrif
- Giotrif
- Tovok
- Tovok,BIBW
- Afatinib whatsapp
- Afatinib (with 1 int.)
- Afatinib E-Isomer
- Hot sale Afatinib with best price and high quality CAS NO.850140-72-6
- Afatinib(BIBW2992MA2)
- BIBW 2992 BIBW 2992
- 850140-72-6
- Afatinib API
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Afatinib
CAS:Formula:C24H25ClFN5O3Purity:>97.0%(HPLC)(N)Color and Shape:White to Orange to Green powder to crystalMolecular weight:485.94Afatinib (BIBW 2992)
CAS:Formula:C24H25ClFN5O3Color and Shape:White To Off-White SolidMolecular weight:485.95Afatinib (Standard)
CAS:Afatinib (Standard) is a reference standard for research and analysis in studies involving Afatinib. Afatinib (BIBW 2992) is an EGFR family inhibitor that inhibits EGFRwt, EGFRL858R, EGFRL858R/T790M, and HER2 (IC50=0.5/0.4/10/14 nM) with irreversible and oral activity. Afatinib has antitumor activity.Formula:C24H25ClFN5O3Molecular weight:485.94Afatinib, Free Base
CAS:Formula:C24H25ClFN5O3Purity:>97.0%(HPLC)(N)Color and Shape:SolidMolecular weight:485.94Afatinib
CAS:Applications An aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
References Nakao, K., et al.: Sci. Rep., 9, 18202 92019); Ebert, K, PLoS One, 14, 0223225 (2019)Formula:C24H25ClFN5O3Color and Shape:NeatMolecular weight:485.94Afatinib
CAS:AfatinibFormula:C24H25ClFN5O3Purity:By hplc: >99% (Typical Value in Batch COA)Color and Shape:Solid-CrystalsMolecular weight:485.9384Afatinib
CAS:Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.Formula:C24H25ClFN5O3Purity:98.56% - 99.90%Color and Shape:White SolidMolecular weight:485.94(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
CAS:(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamideFormula:C24H25ClFN5O3Purity:99%Molecular weight:485.94Afatinib
CAS:Irreversible blocker of three members of the ErbB family (ErbB1, ErbB2/HER2, and ErbB4) with IC50 in nanomolar range. The compound binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling, inhibits cellular growth and promotes apoptosis. Afatinib has been used for the treatment of tyrosine kinase inhibitor-resistant tumours with mutations in ErbB genes, especially for deletions in exon 19 and single nucleotide substitutions in exon 21. It has been used for treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer, colorectal cancer, etc.
Formula:C24H25ClFN5O3Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:485.94 g/molAfatinib - Bio-X ™
CAS:Afatinib is a small molecule that inhibits the activity of cellular kinases that are involved in the progression of cancer. It is an Irreversible inhibitor of three members of the ErbB family. This molecule binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling which inhibits cellular growth and promotes apoptosis. It has been researched for the treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer and colorectal cancer.Formula:C24H25ClFN5O3Purity:Min. 95%Color and Shape:PowderMolecular weight:485.94 g/molAfatinib-d4
CAS:Controlled ProductFormula:C24D4H21ClFN5O3Color and Shape:NeatMolecular weight:489.963
