CAS 851983-85-2

Galeterone

Description:

Galeterone, also known by its chemical name and CAS number 851983-85-2, is a synthetic compound primarily investigated for its potential use in the treatment of prostate cancer. It functions as an androgen receptor antagonist, inhibiting the action of androgens, which are hormones that can promote the growth of prostate cancer cells. Galeterone exhibits a unique mechanism of action by not only blocking androgen receptors but also degrading them, thereby reducing the overall androgen signaling in cancer cells. The compound is characterized by its relatively low molecular weight and specific structural features that contribute to its biological activity. In preclinical and clinical studies, Galeterone has shown promise in managing castration-resistant prostate cancer, particularly in patients who have developed resistance to conventional therapies. Its pharmacokinetic profile, including absorption, distribution, metabolism, and excretion, is an area of ongoing research, as understanding these properties is crucial for optimizing its therapeutic efficacy and safety.

Formula: C₂₆H₃₂N₂O

InChI: InChI=1S/C26H32N2O/c1-25-13-11-18(29)15-17(25)7-8-19-20-9-10-24(26(20,2)14-12-21(19)25)28-16-27-22-5-3-4-6-23(22)28/h3-7,10,16,18-21,29H,8-9,11-15H2,1-2H3/t18-,19-,20-,21-,25-,26-/m0/s1

InChI key: InChIKey=PAFKTGFSEFKSQG-PAASFTFBSA-N

SMILES: C[C@@]12[C@]([C@]3([C@](CC1)([C@]4(C)C(=CC3)C[C@@H](O)CC4)[H])[H])(CC=C2N5C=6C(N=C5)=CC=CC6)[H]

Synonyms:

• (3beta)-17-(1H-BenziMidazol-1-yl)androsta-5,16-dien-3-ol
• (3β)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol
• Androsta-5,16-dien-3-ol, 17-(1H-benzimidazol-1-yl)-, (3β)-
• Galaterone
• Tk-001
• Tok 001
• Vn 124
• Vn/124-1
• Galeterone

Galaterone

CAS: 851983-85-2

Formula: C₂₆H₃₂N₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 388.5451

Ref: IN-DA00G3Q9

Galeterone

CAS: 851983-85-2

Galeterone

Purity: ≥98%

Molecular weight: 388.55g/mol

Ref: 54-BUP10731

Galeterone

CAS: 851983-85-2

Galeterone (VN 124) is an oral androgen receptor modulator/CYP17 inhibitor with antiandrogen properties, targeting prostate cancer growth.

Formula: C₂₆H₃₂N₂O

Purity: 99.47% - 99.773%

Color and Shape: Solid

Molecular weight: 388.55

Ref: TM-T6509

Galeterone

CAS: 851983-85-2

CYP17 lyase inhibitor; androgen receptor antagonist

Formula: C₂₆H₃₂N₂O

Purity: Min. 95%

Molecular weight: 388.55 g/mol

Ref: 3D-FT65187

Galeterone

Controlled Product

CAS: 851983-85-2

Applications Galeterone is an androgen receptor antagonist and CYP17A1 enzyme inhibitor.
References Soifer, H.S., et al.: J. Biol. Chem., 287, 3777 (2012); Vasaitis, T., et al.: Molec. Cancer. Therap., 7, 2348 (2008);

Formula: C₂₆H₃₂N₂O

Color and Shape: Neat

Molecular weight: 388.55

Ref: TR-G188200