CAS 852808-04-9

4-[4-[(4′-Chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide

Description:

The chemical substance with the name "4-[4-[(4′-Chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide" and CAS number 852808-04-9 is a complex organic compound characterized by its multi-functional structure. It features a piperazine ring, which is known for its role in pharmacological activity, and incorporates a sulfonamide group, which can enhance solubility and bioactivity. The presence of a chloro-substituted biphenyl moiety suggests potential interactions with biological targets, while the nitrophenyl and dimethylamino groups may contribute to its overall reactivity and binding properties. This compound is likely to exhibit significant pharmacological properties, making it of interest in medicinal chemistry. Its intricate structure indicates potential for diverse applications, possibly in therapeutic contexts, although specific biological activities would require empirical investigation. As with many complex organic molecules, stability, solubility, and reactivity are key characteristics that would influence its practical use.

Formula: C₄₂H₄₅ClN₆O₅S₂

InChI: InChI=1S/C42H45ClN6O5S2/c1-46(2)23-22-35(30-55-37-9-4-3-5-10-37)44-40-21-20-38(28-41(40)49(51)52)56(53,54)45-42(50)32-14-18-36(19-15-32)48-26-24-47(25-27-48)29-33-8-6-7-11-39(33)31-12-16-34(43)17-13-31/h3-21,28,35,44H,22-27,29-30H2,1-2H3,(H,45,50)/t35-/m1/s1

InChI key: InChIKey=HPLNQCPCUACXLM-PGUFJCEWSA-N

SMILES: C(C1=C(C=CC=C1)C2=CC=C(Cl)C=C2)N3CCN(CC3)C4=CC=C(C(NS(=O)(=O)C5=CC(N(=O)=O)=C(N[C@@H](CSC6=CC=CC=C6)CCN(C)C)C=C5)=O)C=C4

Synonyms:

• 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
• 852808-04-9
• Abt 737
• Benzamide, 4-[4-[(4′-chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-

ABT-737

CAS: 852808-04-9

ABT-737

Formula: C₄₂H₄₅ClN₆O₅S₂

Purity: 99.5%

Molecular weight: 813.43

Ref: 54-BUP10787

(R)-4-(4-((4'-Chloro-[1,1'-Biphenyl]-2-Yl)Methyl)Piperazin-1-Yl)-N-((4-((4-(Dimethylamino)-1-(Phenylthio)Butan-2-Yl)Amino)-3-Nitrophenyl)Sulfonyl)Benzamide

CAS: 852808-04-9

(R)-4-(4-((4'-Chloro-[1,1'-Biphenyl]-2-Yl)Methyl)Piperazin-1-Yl)-N-((4-((4-(Dimethylamino)-1-(Phenylthio)Butan-2-Yl)Amino)-3-Nitrophenyl)Sulfonyl)Benzamide

Formula: C₄₂H₄₅ClN₆O₅S₂

Purity: ≥98%

Molecular weight: 813.43

Ref: 54-OR1023267

ABT 737

Controlled Product

CAS: 852808-04-9

Applications A selective inhibitor of BCL-2, in small cell lung cancer. ABT-737 induced dramatic regressions in tumors derived from some SCLC cell lines. Potent Bcl-2 Family inhibitor.
References Ikegaki, N., et al.: Cancer Res., 54, 6 (1994), Kaiser, U., et al.: Lung Cancer, 15, 31 (1996), Rudin, C., et al.: J. Clin. Oncol., 22, 1110 ( 2004), Konopleva, M., et al.: Cancer Cell, 10, 375 (2006), Trudel, S., et al.: Clin. Cancer Res., 13, 621 (2007),

Formula: C₄₂H₄₅ClN₆O₅S₂

Color and Shape: Neat

Molecular weight: 813.43

Ref: TR-A112550

ABT-737

CAS: 852808-04-9

ABT-737 is a BH3 mimetic and an inhibitor of Bcl-2, Bcl-xL, and Bcl-w. ABT-737 exhibits antitumor activity and anti-aging activity. Cost-effective and quality-assured.

Formula: C₄₂H₄₅ClN₆O₅S₂

Purity: 98.69% - >99.99%

Color and Shape: Solid

Molecular weight: 813.427

Ref: TM-T2099

ABT-737

CAS: 852808-04-9

Ref: 7W-GW8845

ABT 737

CAS: 852808-04-9

Inhibits anti-apoptotic proteins Bcl-2, Bcl-xl and Bcl-w. Synergistic with chemotherapy and radiotherapy in several tumour cell lines. Potent activity as a single agent in lymphoid cancer and small cell lung cancer (SCLC) cell lines. Causes tumour regression in SCLC xenograft tumour in vivo.

Formula: C₄₂H₄₅ClN₆O₅S₂

Purity: Min. 95%

Color and Shape: Yellow Solid

Molecular weight: 813.43 g/mol

Ref: 3D-FA16902

ABT 737

CAS: 852808-04-9

Formula: C₄₂H₄₅ClN₆O₅S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 813.4269

Ref: IN-DA004UYY