CAS 85416-73-5

(+)-Rolipram

Description:

(+)-Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor, primarily known for its potential therapeutic applications in treating conditions such as depression and inflammatory diseases. It is characterized by its ability to increase intracellular levels of cyclic adenosine monophosphate (cAMP), which plays a crucial role in various cellular processes, including neurotransmission and immune response. The compound is typically presented as a white to off-white crystalline solid and is soluble in organic solvents like dimethyl sulfoxide (DMSO) but has limited solubility in water. Its molecular structure features a pyrrolidine ring, contributing to its biological activity. (+)-Rolipram has been studied for its neuroprotective effects and potential in enhancing cognitive function, making it a subject of interest in pharmacological research. However, its use is often limited by side effects and the need for further investigation into its long-term safety and efficacy. Overall, (+)-Rolipram exemplifies the intersection of medicinal chemistry and pharmacology in developing targeted therapies.

Formula: C₁₆H₂₁NO₃

InChI: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m1/s1

InChI key: InChIKey=HJORMJIFDVBMOB-GFCCVEGCSA-N

SMILES: O(C1=C(OC)C=CC(=C1)[C@H]2CNC(=O)C2)C3CCCC3

Synonyms:

• (+)-Rolipram
• 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (S)-
• 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4S)-
• (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
• (S)-Rolipram
• (4S)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
• (+)-ROLIPRAM;(S)-ROLIPRAM
• Rolipram (S)-(+)-
• (4S)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidine-2-one
• (S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
• S- (+)-Rolipram (ME-3167
• (S)-(+)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
• (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
• (4S)-4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone

(S)-(+)-Rolipram

CAS: 85416-73-5

Formula: C₁₆H₂₁NO₃

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 275.35

Ref: 3B-R0183

S-(+)-Rolipram

CAS: 85416-73-5

Formula: C₁₆H₂₁NO₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 275.3428

Ref: IN-DA008F4J

(S)-4-(3-(Cyclopentyloxy)-4-Methoxyphenyl)Pyrrolidin-2-One

CAS: 85416-73-5

(S)-4-(3-(Cyclopentyloxy)-4-Methoxyphenyl)Pyrrolidin-2-One

Purity: 98%

Molecular weight: 275.34g/mol

Ref: 54-OR1026192

(S)-(+)-Rolipram

CAS: 85416-73-5

(S)-(+)-Rolipram

Purity: ≥98%

Molecular weight: 275.34g/mol

Ref: 54-BUP05843

(S)-(+)-Rolipram

CAS: 85416-73-5

(S)-(+)-Rolipram ((+)-Rolipram) inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the

Formula: C₁₆H₂₁NO₃

Purity: 99.14%

Color and Shape: Solid

Molecular weight: 275.34

Ref: TM-T6649

S-(-)-Rolipram

CAS: 85416-73-5

Formula: C₁₆H₂₁NO₃

Molecular weight: 275.35

Ref: 4Z-R-112003

(S)-(+)-Rolipram

CAS: 85416-73-5

M04091 - (S)-(+)-Rolipram

Formula: C₁₆H₂₁NO₃

Purity: 99%

Molecular weight: 275.3479919433594

Ref: 10-M04091

S-Rolipram

CAS: 85416-73-5

Inhibitor of PDE4 enzyme; anti-inflammatory

Formula: C₁₆H₂₁NO₃

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 275.34 g/mol

Ref: 3D-FR65175

S-(-)-Rolipram

CAS: 85416-73-5

Formula: C₁₆H₂₁NO₃

Molecular weight: 275.35

Ref: ST-EA-CP-R106001