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CAS 85416-73-5

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(+)-Rolipram

Description:
(+)-Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor, primarily known for its potential therapeutic applications in treating conditions such as depression and inflammatory diseases. It is characterized by its ability to increase intracellular levels of cyclic adenosine monophosphate (cAMP), which plays a crucial role in various cellular processes, including neurotransmission and immune response. The compound is typically presented as a white to off-white crystalline solid and is soluble in organic solvents like dimethyl sulfoxide (DMSO) but has limited solubility in water. Its molecular structure features a pyrrolidine ring, contributing to its biological activity. (+)-Rolipram has been studied for its neuroprotective effects and potential in enhancing cognitive function, making it a subject of interest in pharmacological research. However, its use is often limited by side effects and the need for further investigation into its long-term safety and efficacy. Overall, (+)-Rolipram exemplifies the intersection of medicinal chemistry and pharmacology in developing targeted therapies.
Formula:C16H21NO3
InChI:InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m1/s1
InChI key:InChIKey=HJORMJIFDVBMOB-GFCCVEGCSA-N
SMILES:O(C1=C(OC)C=CC(=C1)[C@H]2CNC(=O)C2)C3CCCC3
Synonyms:
  • (+)-Rolipram
  • 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (S)-
  • 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4S)-
  • (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
  • (S)-Rolipram
  • (4S)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
  • (+)-ROLIPRAM;(S)-ROLIPRAM
  • Rolipram (S)-(+)-
  • (4S)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidine-2-one
  • (S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
  • See more synonyms
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