CAS 85416-75-7

(-)-Rolipram

Description:

(-)-Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor, primarily known for its potential therapeutic effects in treating conditions such as depression and inflammatory diseases. It is characterized by its chiral nature, with the "(-)" indicating its specific enantiomeric form. The compound has a molecular formula that includes carbon, hydrogen, nitrogen, and oxygen atoms, contributing to its biological activity. (-)-Rolipram is typically a white to off-white crystalline solid, exhibiting moderate solubility in organic solvents and limited solubility in water. Its mechanism of action involves the inhibition of PDE4, leading to increased levels of cyclic adenosine monophosphate (cAMP) within cells, which can enhance neuronal signaling and reduce inflammation. The compound has been studied for its neuroprotective properties and its potential role in cognitive enhancement. However, its clinical use has been limited due to side effects and the development of more selective PDE inhibitors. Overall, (-)-Rolipram remains a significant compound in pharmacological research, particularly in the context of neuropsychiatric and inflammatory disorders.

Formula: C₁₆H₂₁NO₃

InChI: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1

InChI key: InChIKey=HJORMJIFDVBMOB-LBPRGKRZSA-N

SMILES: O(C1=C(OC)C=CC(=C1)[C@@H]2CNC(=O)C2)C3CCCC3

Synonyms:

• 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)-
• 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (R)-
• (-)-Rolipram
• (R)-Rolipram
• (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone

(R)-(-)-Rolipram

CAS: 85416-75-7

Formula: C₁₆H₂₁NO₃

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 275.35

Ref: 3B-R0182

(4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one

CAS: 85416-75-7

Formula: C₁₆H₂₁NO₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 275.3428

Ref: IN-DA0036EM

(R)-(-)-Rolipram

CAS: 85416-75-7

(R)-(-)-Rolipram

Purity: ≥98%

Molecular weight: 275.34g/mol

Ref: 54-BUP02109

R-(-)-Rolipram

CAS: 85416-75-7

Formula: C₁₆H₂₁NO₃

Molecular weight: 275.35

Ref: 4Z-R-112002

R-Rolipram

CAS: 85416-75-7

Inhibitor of PDE4 enzyme; anti-inflammatory

Formula: C₁₆H₂₁NO₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 275.34 g/mol

Ref: 3D-FR65154

(R)-(-)-Rolipram

CAS: 85416-75-7

M03852 - (R)-(-)-Rolipram

Formula: C₁₆H₂₁NO₃

Purity: ≥97%

Color and Shape: Solid

Molecular weight: 275.348

Ref: 10-M03852

R-(-)-Rolipram

Controlled Product

CAS: 85416-75-7

Applications R-(-)-Rolipram is a phosphodiesterase IV (PDE4) inhibitor and anti-inflammatory agent with some antidepressant activity. It is the R isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor.
References Semmler, J., et al.: Int. J. Immunopharmacol.: 15, 409 (1993); Sommer, N., et al.: Nat. Med.: 1, 244 (1995); Robichaud, A., et al.: J. Clin. Invest., 110, 1045 (2002); Card, G., et al.: Structure: 12, 2233 (2004);

Formula: C₁₆H₂₁NO₃

Color and Shape: Neat

Molecular weight: 275.343

Ref: TR-R640043

R-(-)-Rolipram

CAS: 85416-75-7

Formula: C₁₆H₂₁NO₃

Molecular weight: 275.35

Ref: ST-EA-CP-R106002

(R)-(-)-Rolipram

CAS: 85416-75-7

(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.

Formula: C₁₆H₂₁NO₃

Purity: 99.54%

Color and Shape: Solid

Molecular weight: 275.34

Ref: TM-T13448