CAS 85642-08-6

Mono-iodo amiodarone

Description:

Mono-iodo amiodarone, identified by its CAS number 85642-08-6, is a derivative of amiodarone, a well-known antiarrhythmic medication. This compound features a unique structure characterized by the presence of iodine atoms, which contribute to its pharmacological properties. Mono-iodo amiodarone is primarily recognized for its role in the treatment of various cardiac arrhythmias, particularly in patients with atrial fibrillation or ventricular tachycardia. The iodine atoms in its structure enhance its lipophilicity, allowing it to accumulate in cardiac tissues and exert its therapeutic effects. Additionally, this compound exhibits a complex mechanism of action, involving the blockade of potassium channels and modulation of adrenergic receptors, which helps restore normal heart rhythm. Its pharmacokinetics are influenced by its high protein binding capacity and long half-life, making it effective for long-term management of arrhythmias. However, like other iodine-containing compounds, it may pose risks of thyroid dysfunction, necessitating careful monitoring during treatment. Overall, mono-iodo amiodarone represents a significant advancement in antiarrhythmic therapy.

Formula: C₂₅H₃₀INO₃

InChI: InChI=1S/C25H30INO3/c1-4-7-11-23-24(19-10-8-9-12-21(19)30-23)25(28)18-13-14-22(20(26)17-18)29-16-15-27(5-2)6-3/h8-10,12-14,17H,4-7,11,15-16H2,1-3H3

InChI key: DKWLFFXBYKTKRM-UHFFFAOYSA-N

SMILES: CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C=C3)OCCN(CC)CC)I

Synonyms:

• 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3-iodophenyl ketone

Monoiodoamiodarone

CAS: 85642-08-6

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Formula: C₂₅H₃₀INO₃

Color and Shape: Colorless Semi-Solid

Molecular weight: 519.12704

Ref: 45-1A01090

L-6355

CAS: 85642-08-6

L-6355

Purity: 98%

Ref: 54-OR1037187

Deiodo Amiodarone

CAS: 85642-08-6

Formula: C₂₅H₃₀INO₃

Purity: 97%

Color and Shape: Liquid

Molecular weight: 519.4151

Ref: IN-DA00G5AH

Deiodo Amiodarone

Controlled Product

CAS: 85642-08-6

Impurity Amiodarone EP Impurity C /Amiodarone USP Related Compound C
Applications An intermediate of Amiodarone (A632950). Amiodarone EP Impurity C
References Weir, S., et al.: J. Pharm. Sci., 74, 460 (1985), Ramanathan, R., et al.: Anal. Chem., 72, 1352 (2000),

Formula: C₂₅H₃₀INO₃

Color and Shape: Neat

Molecular weight: 519.415

Ref: TR-D229025

L-6355

CAS: 85642-08-6

L-6355 is an agent of bioactive chemicals.

Formula: C₂₅H₃₀INO₃

Color and Shape: Solid

Molecular weight: 519.42

Ref: TM-T20141

(2-Butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3-iodophenyl)methanone

CAS: 85642-08-6

(2-Butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3-iodophenyl)methanone

Formula: C₂₅H₃₀INO₃

Purity: 97%

Molecular weight: 519.42

Ref: IN-DG02667120

Deiodo amiodarone

CAS: 85642-08-6

Deiodo amiodarone is a noncompetitive inhibitor that binds to the active site of the enzyme and blocks the binding of substrate, thereby inhibiting the synthesis of catecholamines. Deiodo amiodarone has been shown to inhibit the oxidation of benzofuran derivatives in rat liver microsomes, human liver tissue samples, and chromatographic conditions. The inhibition constant for deiodo amiodarone was determined by liquid chromatography with a homogenizing technique.

Formula: C₂₅H₃₀INO₃

Purity: Min. 95%

Molecular weight: 519.42 g/mol

Ref: 3D-ID20972

Amiodarone EP Impurity C

CAS: 85642-08-6

Formula: C₂₅H₃₀INO₃

Molecular weight: 519.42

Ref: ST-EA-CP-A56040