CAS 85650-56-2

Asenapine maleate

Description:

Asenapine maleate is an atypical antipsychotic medication primarily used in the treatment of schizophrenia and bipolar disorder. It is a salt form of asenapine, which is a dibenzo-oxepine derivative. The compound exhibits a complex structure that allows it to interact with various neurotransmitter receptors in the brain, particularly serotonin and dopamine receptors, which are crucial in mood regulation and psychotic disorders. Asenapine maleate is typically administered sublingually, allowing for rapid absorption and onset of action. Its pharmacological profile includes antagonistic activity at multiple receptor sites, contributing to its efficacy in managing symptoms of psychosis and mood stabilization. The substance is characterized by its low solubility in water, which influences its formulation and delivery methods. Common side effects may include sedation, weight gain, and metabolic changes, necessitating careful monitoring during treatment. Overall, asenapine maleate represents a significant option in psychiatric pharmacotherapy, with a unique mechanism of action and a specific therapeutic application.

Formula: C₁₇H₁₆ClNO·C₄H₄O₄

InChI: InChI=1/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;5-3(6)1-2-4(7)8/h2-8,14-15H,9-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-;/s2

InChI key: InChIKey=GMDCDXMAFMEDAG-UHGYJBHVNA-N

SMILES: CN1C[C@]2([C@@](C=3C(OC=4C2=CC(Cl)=CC4)=CC=CC3)(C1)[H])[H].C(=C\C(O)=O)\C(O)=O

Synonyms:

• (3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-but-2-enedioate
• (3aS,12bS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-but-2-enedioate
• 1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, (3aR,12bR)-rel-, (2Z)-2-butenedioate (1:1)
• 1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, trans-, (Z)-2-butenedioate (1:1)
• Asenapine Maleate
• Org 5222

Asenapine Maleate

CAS: 85650-56-2

Formula: C₁₇H₁₆ClNO·C₄H₄O₄

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 401.84

Ref: 3B-A3406

Asenapine Maleate 1.0 mg/ml in Methanol (as free base)

CAS: 85650-56-2

Color and Shape: Single Solution

Ref: 61-AMP3491.00-01

9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.0^{2,6}.0^{7,12}]octadeca-1(18),7,9,11,14,16-hexaene; but-2-enedioic acid

CAS: 85650-56-2

Formula: C₂₁H₂₀ClNO₅

Purity: 99%

Color and Shape: Solid

Molecular weight: 401.8402

Ref: IN-DA0036DT

Asenapine Maleate

CAS: 85650-56-2

Asenapine Maleate (Org 5222 maleate) is a second generation (atypical) antipsychotic agent that is taken sublingually.

Formula: C₂₁H₂₀ClNO₅

Purity: 99.28%

Color and Shape: Solid

Molecular weight: 401.84

Ref: TM-T1951

Asenapine Maleate

CAS: 85650-56-2

Asenapine Maleate

Purity: ≥98%

Molecular weight: 401.84g/mol

Ref: 54-BUP15554

Asenapine maleate

CAS: 85650-56-2

Asenapine maleate

Purity: 99%

Molecular weight: 401.84g/mol

Ref: 54-OR1025022

Asenapine Maleate

CAS: 85650-56-2

Formula: C₁₇H₁₆ClNO·C₄H₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 285.78 116.07

Ref: 4Z-A-501

Asenapine Maleate

CAS: 85650-56-2

Color and Shape: Neat

Ref: 61-FOR3491.00

Asenapine Maleate

Controlled Product

CAS: 85650-56-2

Formula: C₁₇H₁₆ClNO·C₄H₄O₄

Color and Shape: Neat

Molecular weight: 401.84

Ref: 86-MM3491.00

Asenapine maleate

CAS: 85650-56-2

Formula: C₁₇H₁₆ClNO·C₄H₄O₄

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 401.84

Ref: 7W-GP0603

Asenapine Maleate

CAS: 85650-56-2

Formula: C₁₇H₁₆ClNOC₄H₄O₄

Molecular weight: 285.8 : 116.1

Ref: ST-EA-CP-A78000

Asenapine-13C,d3 Maleate

Controlled Product

CAS: 85650-56-2

Applications Asenapine-13C,d3 maleate, is the labeled analogue of Asenapine-13C,d3 Maleate, a 5-HT receptor antagonist developed for the treatment of acute schizophrenia and bipolar mania.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tarazi. F.I., et al.: Drugs. Today., 45, 865 (2009); Boboaca, S.D., et al.: Int. J. Molec. Sci., 12, 4348 (2011); Audinot, V., et al.: Neuropsycopharmacol., 25, 410 (2001);

Formula: CC₁₆D₃H₁₃ClNO·C₄H₃O₄

Color and Shape: Neat

Molecular weight: 404.843

Ref: TR-A788027

Asenapine maleate

Controlled Product

CAS: 85650-56-2

Inhibits dopamine, serotonin and adrenergic receptors

Formula: C₁₇H₁₆ClNOC₄H₄O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 401.84 g/mol

Ref: 3D-FA61540

Asenapine Maleate

Controlled Product

CAS: 85650-56-2

Applications Asenapine Maleate, is a 5-HT receptor antagonist developed for the treatment of acute schizophrenia and bipolar mania. Antagonist of serotonin, norepinephrine, dopamine and histamine receptors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tarazi. F.I., et al.: Drugs. Today., 45, 865 (2009); Boboaca, S.D., et al.: Int. J. Molec. Sci., 12, 4348 (2011); Audinot, V., et al.: Neuropsycopharmacol., 25, 410 (2001);

Formula: C₁₇H₁₆ClNO·C₄H₄O₄

Color and Shape: Neat

Molecular weight: 401.84

Ref: TR-A788025