CAS 856867-55-5

Tedizolid phosphate

Description:

Tedizolid phosphate is an oxazolidinone antibiotic that is primarily used for the treatment of acute bacterial skin and skin structure infections. It is a prodrug of tedizolid, which means it is converted into its active form in the body. The compound exhibits potent activity against a range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Tedizolid phosphate is characterized by its ability to inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing the formation of functional ribosomes. This mechanism of action makes it effective against resistant strains of bacteria. The substance is typically administered orally or intravenously and has a favorable pharmacokinetic profile, including a long half-life that allows for once-daily dosing. Additionally, tedizolid phosphate has been noted for its relatively low potential for drug-drug interactions and a favorable safety profile, making it a valuable option in the treatment of serious infections caused by resistant pathogens.

Formula:C₁₇H₁₈FN₆O₇P

InChI:InChI=1S/C17H16FN6O6P/c1-23-21-16(20-22-23)15-5-2-10(7-19-15)13-4-3-11(6-14(13)18)24-8-12(30-17(24)25)9-29-31(26,27)28/h2-7,12H,8-9H2,1H3,(H2,26,27,28)/t12-/m1/s1

InChI key:InChIKey=QCGUSIANLFXSGE-GFCCVEGCSA-N

SMILES:O=C1N(C2=CC(F)=C(C=C2)C=3C=CC(=NC3)C=4N=NN(C)N4)C[C@H](COP(=O)(O)O)O1

Synonyms:

(5R)-3-[3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-[(phosphonooxy)methyl]-2-oxazolidinone
(R)-(3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl dihydrogen phosphate
2-Oxazolidinone, 3-[3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-[(phosphonooxy)methyl]-, (5R)-
Tedizolid hydrogen phosphate
Tr 701Fa
Tedizolid phosphate
Torezolid phosphate
(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one dihydrogenphosphate
[(5R)-3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)pyridin-3-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl dihydrogen phosphate
Tedizolid Phosphate (TR-701)
Tedizolid phosphate impurity A
(R) -3- (4- (2- (2- methyl-tetrazol-5-yl) pyridin-5-yl) -3-fluorophenyl) -5-hydroxymethyl-oxazolidin-2-one phosphate
Tedizolid phosphate (5R)-3-[3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-[(phosphonooxy)methyl]-2-oxazolidinone
-3-(4-(2-(2-Methyltetrazol-5-yl)pyridine-5-yl)-3-fluorophenyl)-5-hydroxyMethyl oxazolidin-2-one phosphate
(R)-(3-(3-Fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)met
(R) -3-(4-(2-(2-Methyltetrazol-5-yl)pyridine-5-yl)-3-fluorophenyl)-5-hydroxyMethyl oxazolidin-2-one phosphate
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