CAS 857290-04-1

N-(6-amino-2-pyridyl)-4-(4-cyanophenyl)benzenesulfonamide

Description:

N-(6-amino-2-pyridyl)-4-(4-cyanophenyl)benzenesulfonamide, with the CAS number 857290-04-1, is a chemical compound characterized by its complex structure, which includes a sulfonamide functional group, a pyridine ring, and a cyanophenyl moiety. This compound typically exhibits properties associated with sulfonamides, such as potential antibacterial activity, due to the presence of the sulfonamide group. The amino group on the pyridine ring may contribute to its reactivity and solubility in various solvents. The presence of the cyanophenyl group can enhance its electronic properties, potentially influencing its interaction with biological targets. This compound may be of interest in medicinal chemistry for its potential therapeutic applications, particularly in the development of drugs targeting specific biological pathways. Additionally, its molecular structure suggests it could participate in hydrogen bonding and other intermolecular interactions, which are crucial for its biological activity and solubility characteristics. Overall, this compound represents a unique combination of functional groups that may offer diverse applications in pharmaceutical research.

Formula: C₁₈H₁₄N₄O₂S

InChI: InChI=1/C18H14N4O2S/c19-12-13-4-6-14(7-5-13)15-8-10-16(11-9-15)25(23,24)22-18-3-1-2-17(20)21-18/h1-11H,(H3,20,21,22)

SMILES: c1cc(=N)[nH]c(c1)NS(=O)(=O)c1ccc(cc1)c1ccc(cc1)C#N

Synonyms:

• 4'-Cyanobiphenyl-4-Sulfonic Acid (6-Aminopyridin-2-Yl)Amide
• N-(6-aminopyridin-2-yl)-4'-cyanobiphenyl-4-sulfonamide

N-(6-AMINO-PYRIDIN-2-YL)-4'-CYANO-[1,1'-BIPHENYL]-4-SULFONAMIDE

CAS: 857290-04-1

Formula: C₁₈H₁₄N₄O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 350.3944

Ref: IN-DA004P4Z

PF-915275

CAS: 857290-04-1

PF-915275

Purity: ≥95%

Molecular weight: 350.39g/mol

Ref: 54-BUP09564

PF 915275

CAS: 857290-04-1

PF 915275 is a novel, orally active drug for the treatment of type 2 diabetes. It is an inhibitor of glucocorticoid receptor activity and has shown promising results in animal models for type 2 diabetes treatment. PF 915275 also has a potential role in treating metabolic disorders such as obesity, glucose intolerance, and hyperlipidemia. This drug is a potent inhibitor of the transcriptional activity of the glucocorticoid receptor, which leads to decreased cortisol levels in blood cells. The mechanism of action of PF 915275 involves the inhibition of phosphorylation by p-nitrophenyl phosphate (PNPP) on the glucocorticoid receptor and subsequent reduction in cAMP production. This results in decreased PGE2 levels and increased insulin secretion by pancreatic β-cells. PF 915275 binds to thyroid hormone receptors with high affinity and may have therapeutic implications for thyroid diseases such as Graves’ disease or Hashimoto’s thyroiditis.

Formula: C₁₈H₁₄N₄O₂S

Purity: Min. 95%

Molecular weight: 350.4 g/mol

Ref: 3D-BP179814

PF-915275

CAS: 857290-04-1

PF-915275 inhibits 11βHSD1 in humans (Ki=2.3 nM, EC50=15 nM) and affects cortisone-cortisol conversion in hepatocytes.

Formula: C₁₈H₁₄N₄O₂S

Purity: 99.58% - 99.61%

Color and Shape: Solid

Molecular weight: 350.39

Ref: TM-T16510