CAS 857876-30-3

Motesanib diphosphate

Description:

Motesanib diphosphate is a small molecule that functions primarily as an inhibitor of various receptor tyrosine kinases, which are critical in processes such as cell growth, differentiation, and metabolism. It is particularly noted for its role in targeting vascular endothelial growth factor (VEGF) receptors, thereby inhibiting angiogenesis, the formation of new blood vessels, which is a vital process in tumor growth and metastasis. The compound is characterized by its diphosphate form, which enhances its solubility and bioavailability in biological systems. Motesanib diphosphate has been investigated for its potential therapeutic applications in oncology, particularly in the treatment of solid tumors. Its mechanism of action involves blocking signaling pathways that promote cancer cell proliferation and survival. Additionally, the compound's pharmacokinetics, including absorption, distribution, metabolism, and excretion, are crucial for determining its efficacy and safety profile in clinical settings. As with many targeted therapies, ongoing research continues to evaluate its effectiveness and potential side effects in various cancer types.

Formula: C₂₂H₂₃N₅O·2H₃O₄P

InChI: InChI=1S/C22H23N5O.H3O4P/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15;1-5(2,3)4/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28);(H3,1,2,3,4)

InChI key: InChIKey=UJMNMHXUOCSCFT-UHFFFAOYSA-N

SMILES: CC1(C)C=2C(=CC(NC(=O)C3=C(NCC=4C=CN=CC4)N=CC=C3)=CC2)NC1.P(=O)(O)(O)O

Synonyms:

• 3-Pyridinecarboxamide, N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-, phosphate (1:2)
• Amg 706
• Motesanib Diphosphate

Motesanib Diphosphate

CAS: 857876-30-3

Motesanib Diphosphate

Formula: C₂₂H₂₃N₅O·2H₃PO₄

Purity: ≥98%

Molecular weight: 569.44

Ref: 54-BUP10451

Motesanib Diphosphate Salt

CAS: 857876-30-3

Motesanib Diphosphate Salt

Formula: C₂₂H₂₃N₅O·2H₃PO₄

Purity: 99.90% (Typical Value in Batch COA)

Color and Shape: White Solid-Crystals

Molecular weight: 569.44128

Ref: 54-BIFK0030

Motesanib Diphosphate

CAS: 857876-30-3

Motesanib Diphosphate (AMG 706) is the orally bioavailable diphosphate salt of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic

Formula: C₂₂H₂₃N₅O·2H₃PO₄

Purity: 99.69%

Color and Shape: Solid

Molecular weight: 569.44

Ref: TM-T2288L

Motesanib diphosphate

CAS: 857876-30-3

Formula: C₂₂H₂₆N₅O₅P

Purity: 97%

Color and Shape: Solid

Molecular weight: 471.4461

Ref: IN-DA00G2KX

Motesanib diphosphate

Controlled Product

CAS: 857876-30-3

Inhibitor of VEGFR, PDGR, c-Kit and Ret; inhibitor of angiogenesis

Formula: C₂₂H₂₉N₅O₉P₂

Purity: Min. 95%

Molecular weight: 569.44 g/mol

Ref: 3D-FM26093