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CAS 857890-39-2

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Lenvatinib mesylate

Description:
Lenvatinib mesylate is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of cancer, including thyroid cancer and renal cell carcinoma. It works by inhibiting multiple receptor tyrosine kinases involved in tumor growth and angiogenesis, such as VEGFR, FGFR, PDGFR, and RET. The substance is characterized by its mesylate salt form, which enhances its solubility and bioavailability. Lenvatinib mesylate is typically administered orally and is known for its pharmacokinetic properties, including a relatively long half-life, allowing for once-daily dosing. Common side effects may include hypertension, fatigue, diarrhea, and decreased appetite. The compound is classified as a targeted therapy, reflecting its mechanism of action that specifically disrupts cancer cell signaling pathways. Its development has been a significant advancement in oncology, providing a therapeutic option for patients with advanced malignancies. As with any medication, careful monitoring and management of side effects are essential during treatment.
Formula:C21H19ClN4O4·CH4O3S
InChI:InChI=1S/C21H19ClN4O4.CH4O3S/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11;1-5(2,3)4/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28);1H3,(H,2,3,4)
InChI key:InChIKey=HWLFIUUAYLEFCT-UHFFFAOYSA-N
SMILES:O(C=1C2=C(C=C(OC)C(C(N)=O)=C2)N=CC1)C3=CC(Cl)=C(NC(NC4CC4)=O)C=C3.S(C)(=O)(=O)O
Synonyms:
  • 4-(3-Chloro-4-(Cyclopropylaminocarbonyl)Aminophenoxy)-7-Methoxy-6-Quinolinecarboxamide Mesylate
  • 4-[3-Chloro-4-[(cyclopropylaminocarbonyl)amino]phenoxy]-7-methoxy-6-quinolinecarboxamide mesylate
  • 6-Quinolinecarboxamide, 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-, methanesulfonate (1:1)
  • 6-Quinolinecarboxamide,4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-,monomethanesulfonate
  • E 7080 mesylate
  • Kisplyx
  • Lenvatinib methanesulfonate
  • Lenvima
  • Lenvatinib mesylate
Found 12 products.