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CAS 86060-83-5

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Fmoc-Asp-OBzl

Description:
Fmoc-Asp-OBzl, or Fmoc-aspartic acid benzyl ester, is a derivative of aspartic acid commonly used in peptide synthesis and research. The "Fmoc" (9-fluorenylmethoxycarbonyl) group serves as a protective group for the amino functionality, allowing for selective reactions without interfering with other functional groups. The "Asp" refers to the aspartic acid residue, which is an α-amino acid with both carboxyl and amino groups, contributing to its role in peptide formation. The "OBzl" indicates the presence of a benzyl ester, which protects the carboxylic acid group of aspartic acid, enhancing its stability and solubility in organic solvents. Fmoc-Asp-OBzl is typically used in solid-phase peptide synthesis, where its protective groups can be selectively removed under mild conditions to facilitate the stepwise assembly of peptides. This compound is characterized by its relatively high stability, ease of handling, and compatibility with various coupling reagents, making it a valuable building block in the synthesis of complex peptides and proteins.
Formula:C26H23NO6
InChI:InChI=1/C26H23NO6/c28-24(29)14-23(25(30)32-15-17-8-2-1-3-9-17)27-26(31)33-16-22-20-12-6-4-10-18(20)19-11-5-7-13-21(19)22/h1-13,22-23H,14-16H2,(H,27,31)(H,28,29)/t23-/m0/s1
InChI key:CBZSVHFNEMONDZ-QHCPKHFHSA-N
SMILES:c1ccc(cc1)COC(=O)[C@H](CC(=O)O)N=C(O)OCC1c2ccccc2c2ccccc12
Synonyms:
  • (3S)-4-(benzyloxy)-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-oxobutanoic acid (non-preferred name)
  • Fmoc-L-Aspartic Acid-1-Benzyl Ester
  • N-9-FLUORENYLMETHYLOXYCARBONYL-L-ASPARTIC ACID 1-BENZYL ESTER
  • FMOC-ASP-OBZL
  • FMOC-ASPARTIC ACID-OBZL
  • FMOC-L-ASPARTIC ACID ALPHA-BENZYL ESTER
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ASPARTIC ACID-ALPHA-BENZYL ESTER
  • FMOC-L-ASP-OBZL
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-ASPARTIC ACID ALPHA-BENZYL ESTER
  • N-ALPHA-FMOC-L-ASPARTIC ACID ALPHA-BENZYL ESTER
  • Fmoc Aspartic α-benzyl ester
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