CAS 863031-24-7

Azilsartan kamedoxomil

Description:

Azilsartan kamedoxomil is an antihypertensive medication primarily used for the treatment of high blood pressure. It belongs to the class of angiotensin II receptor antagonists (ARBs), which work by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict. This results in vasodilation and a subsequent decrease in blood pressure. The substance is characterized by its prodrug nature, meaning it is converted into its active form, azilsartan, after administration. Azilsartan kamedoxomil exhibits high selectivity for the angiotensin II receptor subtype AT1, contributing to its efficacy and safety profile. It is typically administered orally and has a favorable pharmacokinetic profile, including a long half-life that allows for once-daily dosing. Common side effects may include dizziness, fatigue, and gastrointestinal disturbances, but it is generally well-tolerated. As with other ARBs, it is contraindicated in pregnancy and should be used with caution in patients with renal impairment. Overall, azilsartan kamedoxomil represents a significant advancement in the management of hypertension.

Formula: C₃₀H₂₃N₄O₈·K

InChI: InChI:1S/C30H24N4O8.K/c1-3-38-28-31-23-10-6-9-22(27(35)39-16-24-17(2)40-30(37)41-24)25(23)34(28)15-18-11-13-19(14-12-18)20-7-4-5-8-21(20)26-32-29(36)42-33-26;/h4-14H,3,15-16H2,1-2H3,(H,32,33,36);/q;+1/p-1

InChI key: InChIKey=MIJNRHZSZJLCAG-UHFFFAOYSA-N

SMILES: C(N1C=2C(N=C1OCC)=CC=CC2C(OCC=3OC(=O)OC3C)=O)C4=CC=C(C=C4)C5=C(C=CC=C5)C=6NC(=O)ON6.[K]

Synonyms:

• 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester potassium salt
• 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl] -2-ethoxy-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester, potassium salt
• 1H-Benzimidazole-7-carboxylic acid, 1-[[2′-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1′-biphenyl]-4-yl]methyl]-2-ethoxy-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester, potassium salt (1:1)
• Azilsartan medoxomil monopotassium salt
• Azilsartan kamedoxomil
• Azilsartan MedoxMil PotassuiM
• Azilsartan Mehtyl ester
• Azilsartan Medoxomil Potassium
• Azilsartan MedoxoMil PotassiuM salt
• Azilsartan kaMedoxoMil (with 5 ints.)
• Azilsartan MedoxiMil PotassiuM
• Azilsartan MedoxoMil (MonopotassiuM)
• Azilsartan Impurity 50 Potassium Salt

Azilsartan Medoxomil Potassium

CAS: 863031-24-7

Azilsartan Medoxomil Potassium (TAK-491 Potassium) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.

Formula: C₃₀H₂₃N₄O₈·K

Purity: 99.99%

Color and Shape: Solid

Molecular weight: 606.62

Ref: TM-T0481

Azilsartan Medoxomil Potassium

CAS: 863031-24-7

Azilsartan Medoxomil Potassium

Purity: ≥98%

Molecular weight: 606.62g/mol

Ref: 54-BUP12061

Azilsartan Medoxomil Potassium Salt

CAS: 863031-24-7

Formula: C₃₀H₂₃N₄O₈·K

Color and Shape: White To Off-White Solid

Molecular weight: 567.53 39.10

Ref: 4Z-A-8454

Azilsartan Kamedoxomil

CAS: 863031-24-7

Formula: C₃₀H₂₃N₄O₈K

Molecular weight: 567.53 : 39.1

Ref: ST-EA-CP-A36024

Azilsartan Kamedoxomil (>90%)

Controlled Product

CAS: 863031-24-7

Formula: C₃₀H₂₃KN₄O₈

Purity: >90%

Color and Shape: White To Off-White

Molecular weight: 606.62

Ref: TR-A965605

Azilsartan kamedoxomil

CAS: 863031-24-7

Azilsartan is a drug used for the treatment of hypertension, diabetes, and other metabolic disorders. It has been shown to reduce chemoattractant protein levels that are associated with autoimmune diseases and renal cell cancer, as well as sodium citrate levels in bowel disease. Azilsartan medoxomil is a prodrug of azilsartan that is metabolized by esterases in the liver to form azilsartan. The analytical method used to detect azilsartan is an HPLC-MS/MS assay, which can also be used to detect the active metabolite medoxomil. Azilsartan should not be taken if there are any signs of liver impairment or kidney failure.

Formula: C₃₀H₂₄N₄O₈•K

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 607.63 g/mol

Ref: 3D-FA31501