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CAS 863031-24-7

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Azilsartan kamedoxomil

Description:
Azilsartan kamedoxomil is an antihypertensive medication primarily used for the treatment of high blood pressure. It belongs to the class of angiotensin II receptor antagonists (ARBs), which work by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict. This results in vasodilation and a subsequent decrease in blood pressure. The substance is characterized by its prodrug nature, meaning it is converted into its active form, azilsartan, after administration. Azilsartan kamedoxomil exhibits high selectivity for the angiotensin II receptor subtype AT1, contributing to its efficacy and safety profile. It is typically administered orally and has a favorable pharmacokinetic profile, including a long half-life that allows for once-daily dosing. Common side effects may include dizziness, fatigue, and gastrointestinal disturbances, but it is generally well-tolerated. As with other ARBs, it is contraindicated in pregnancy and should be used with caution in patients with renal impairment. Overall, azilsartan kamedoxomil represents a significant advancement in the management of hypertension.
Formula:C30H23N4O8·K
InChI:InChI:1S/C30H24N4O8.K/c1-3-38-28-31-23-10-6-9-22(27(35)39-16-24-17(2)40-30(37)41-24)25(23)34(28)15-18-11-13-19(14-12-18)20-7-4-5-8-21(20)26-32-29(36)42-33-26;/h4-14H,3,15-16H2,1-2H3,(H,32,33,36);/q;+1/p-1
InChI key:InChIKey=MIJNRHZSZJLCAG-UHFFFAOYSA-N
SMILES:C(N1C=2C(N=C1OCC)=CC=CC2C(OCC=3OC(=O)OC3C)=O)C4=CC=C(C=C4)C5=C(C=CC=C5)C=6NC(=O)ON6.[K]
Synonyms:
  • 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester potassium salt
  • 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl] -2-ethoxy-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester, potassium salt
  • 1H-Benzimidazole-7-carboxylic acid, 1-[[2′-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1′-biphenyl]-4-yl]methyl]-2-ethoxy-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester, potassium salt (1:1)
  • Azilsartan medoxomil monopotassium salt
  • Azilsartan kamedoxomil
  • Azilsartan MedoxMil PotassuiM
  • Azilsartan Mehtyl ester
  • Azilsartan Medoxomil Potassium
  • Azilsartan MedoxoMil PotassiuM salt
  • Azilsartan kaMedoxoMil (with 5 ints.)
  • See more synonyms
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