CAS 863329-66-2

(2′R)-2′-Deoxy-2′-fluoro-2′-methyluridine

Description:

(2′R)-2′-Deoxy-2′-fluoro-2′-methyluridine is a modified nucleoside that features a fluorine atom and a methyl group at the 2′ position of the ribose sugar, which distinguishes it from natural nucleosides. This compound is characterized by its structural modifications that enhance its stability and bioactivity, making it of interest in medicinal chemistry and molecular biology. The presence of the fluorine atom can influence the compound's interaction with nucleic acids and enzymes, potentially improving its efficacy as an antiviral or anticancer agent. Additionally, the methyl group may affect the compound's solubility and permeability, which are critical factors for therapeutic applications. The stereochemistry at the 2′ position (designated as (2′R)) indicates a specific spatial arrangement that can impact the biological activity and recognition by nucleic acid polymerases. Overall, (2′R)-2′-Deoxy-2′-fluoro-2′-methyluridine represents a valuable tool for research and development in nucleoside analogs.

Formula: C₁₀H₁₃FN₂O₅

InChI: InChI=1S/C10H13FN2O5/c1-10(11)7(16)5(4-14)18-8(10)13-3-2-6(15)12-9(13)17/h2-3,5,7-8,14,16H,4H2,1H3,(H,12,15,17)/t5-,7-,8-,10-/m1/s1

InChI key: InChIKey=ARKKGZQTGXJVKW-VPCXQMTMSA-N

SMILES: C[C@]1(F)[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C=C2

Synonyms:

• (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine
• (2'R)-2'-deoxy-2'-fluoro-2'-methyl-Uridine
• (2R)-2-Deoxy-2-fluoro-2-methyluridine
• 1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
• 2'-Deoxy-2'-Fluoro-2'-C-Methyl Uridine
• 2'-Deoxy-2'-Fluoro-2'-Methyluridine
• 2-Deoxy-2-Fluoro-2-Methyl Uridine
• Gs 331007
• Psi-6206
• Ro 2433
• Sofosbuvir N-1
• Uridine, 2′-deoxy-2′-fluoro-2′-methyl-, (2′R)-
• Sofosbuvir Intermediate 4
• (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine&gt
• N4-Benzoyl-1-(2'
• -deoxy-6-methoxyguanosine
• -fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine
• -fluoro-b-D-arabinofuranosyl)purine
• -O-trityl-b-L-lyxofuranosyl)-uracil
• (2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine
• -fluoro-b-D-arabinofuranosyl)cytosine HCl
• -fluoro-b-D-arabinofuranosyl)-5-ethyluracil
• -deoxy-7-ethynyladenosine
• 5. (2'R)-2'-Deoxy-2'-fluoro-2'-Methyluridine
• -biphenyl]-4-yl]methyl]-4-methyl-2-propyl-1H-benzimidazole-6-carboxylic Acid Methyl Ester
• -fluoro-b-D-arabinofuranosyl)guanine
• -fluoro-b-D-arabinofuranosyl)cytosine
• -(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'
• -biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic Acid
• 1-(2'
• PSI 6206 int
• -deoxy-7-iodoguanosine
• -fluoro-b-D-ribofuranosyl)-2-fluoroadenine
• -fluoro-b-D-arabinofuranosyl)-5-iodouracil
• 1-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-2-yl]pyrimidine-2,4-dione
• 2-Fluoro-9-(2'
• 7-Deaza-2'
• -fluoro-beta-d-arabinofuranosyl)-5-ethyluracil
• -fluoroguanosine
• Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)-
• 9-(2'
• 2'-deoxy-2'-fluoro-2'-C-methyluridine ISO 9001：2015 REACH
• Sofosbuvir Nucleoside Derivative (GS-331007)
• -fluoro-b-D-arabinofuranosyl)hypoxantine
• (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine (Sofo C1)
• dcoxy-2-fuoro-2-C-methyhurdine
• -(Methoxycarbonyl)[1,1'
• -fluoro-b-L-arabinofuranosyl)-uracil
• -chloro-b-L-arabinofuranosyl)-thymine
• -fluoro-b-D-arabinofuranosyl)adenine
• -fluoro-b-D-arabinofuranosyl)thymine 3'
• -biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic Acid-d5
• -O-trityl-b-L-arabinofuranosyl)-uracil
• -fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine 3'
• 2'-deoxy-2'-fluoro-2'-C-methyluridine
• 1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
• Sofosbuvir int. N-1
• -deoxy-O6-methylguanosine
• PSI-6206 (RO-2433, GS-331007)
• 2'-DEOXY-2'-FLUORO-2'-C-METHYLURIDINE,CAS 863329-66-2
• Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- PSI6206
• Sofosbuvir INT 1
• 2'-Deoxy-2'-F-2'-C-methyluridine
• -deoxy-7-iodoadenosine
• Sofosbuvir imp-11
• -fluoro-a-L-arabinofuranosyl)-thymine
• 2'-Deoxy-2-floro-2'Methyl-uridine
• -deoxy-2'
• 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione RO 2433
• -C-ethynyladenosine
• -(Aminoiminomethyl)[1,1'
• Sofosbuvir Metabolite GS331007
• Sofosbuvir Intermediates 2
• PSI-6206; RO-2433; PSI6206; RO2433
• -biphenyl-4-yl)methyl]-2-ethoxy-d5-7-benzimidazolecarboxylic Acid Methyl Ester
• 1-((2S,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
• -fluoro-b-D-ribofuranosyl)purine
• CS-832
• -O-4-C-Methylene-b-D-ribofuranosyl)thymine
• -biphenyl-4-yl)methyl]-2-ethoxy-7-benzimidazolecarboxylic Acid Methyl Ester
• -fluoro-b-D-ribofuranosyl)-isoguanine
• β-D-2'-deoxy-2'-α-F-2'-β-C-methyluridine
• -C-methyluridine
• -fluoro-b-D-arabinofuranosyl)uracil 3'
• 2'-deoxy-2'-fluoro-2'-C-Methyluridine　(N-1)
• -biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

PSI-6206

CAS: 863329-66-2

Formula: C₁₀H₁₃FN₂O₅

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 260.22

Ref: 3B-D4823

(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-uridine

CAS: 863329-66-2

Formula: C₁₀H₁₃FN₂O₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 260.2190

Ref: IN-DA0039OB

PSI-6206

CAS: 863329-66-2

PSI-6206

Formula: C₁₀H₁₃FN₂O₅

Purity: ≥98%, 10 mM in DMSO

Molecular weight: 260.22

Ref: 54-BUP11847

Sofosbuvir Nucleoside Derivative (GS-331007)

CAS: 863329-66-2

Formula: C₁₀H₁₃FN₂O₅

Color and Shape: Off-White To Yellow Solid

Molecular weight: 260.22

Ref: 4Z-S-055001

(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine

CAS: 863329-66-2

(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine

Formula: C₁₀H₁₃FN₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 260.22

Ref: 54-PC104925

PSI-6206

CAS: 863329-66-2

1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Formula: C₁₀H₁₃FN₂O₅

Purity: 97%

Molecular weight: 260.22

Ref: IN-DG225768

PSI-6206

CAS: 863329-66-2

PSI-6206 (RO 2433) (RO2433) is a selective HCV RNA polymerase inhibitor.

Formula: C₁₀H₁₃FN₂O₅

Purity: 98% - 99.79%

Color and Shape: Solid

Molecular weight: 260.22

Ref: TM-T2117

Sofosbuvir Impurity 11

CAS: 863329-66-2

Formula: C₁₀H₁₃FN₂O₅

Molecular weight: 260.22

Ref: ST-EA-CP-S45010

RO 2433

Controlled Product

CAS: 863329-66-2

Impurity Sofosbuvir Metabolite GS331007
Applications RO 2433 is the deaminated metabolite of β-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) replication in vitro.
References Asif, G., et. al.: Antimicrob. Agents Ch., 51, 2877 (2007)

Formula: C₁₀H₁₃FN₂O₅

Color and Shape: Neat

Molecular weight: 260.22

Ref: TR-R637200

GS 331007

CAS: 863329-66-2

Anti-viral; RNA polymerase inhibitor; sofosbuvir metabolite

Formula: C₁₀H₁₃FN₂O₅

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 260.22 g/mol

Ref: 3D-ND29433

1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

CAS: 863329-66-2

Formula: C₁₀H₁₃FN₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 260.221

Ref: 10-F238618