CAS 86383-32-6

1-Propanone,1-[5-hydroxy-2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-,hydrochloride (9CI)

Description:

1-Propanone, 1-[5-hydroxy-2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (9CI), with CAS number 86383-32-6, is a chemical compound characterized by its complex structure that includes a propanone moiety and multiple functional groups such as hydroxyl and amino groups. This compound is typically classified as a phenolic derivative due to the presence of a phenyl ring, which contributes to its potential biological activity. The hydrochloride form indicates that it is a salt, which can enhance its solubility in water and stability. The presence of the propylamino group suggests potential interactions with biological systems, making it of interest in pharmaceutical research. Its molecular structure may allow for various applications, particularly in medicinal chemistry, where it could serve as a lead compound for drug development. However, specific properties such as melting point, boiling point, and solubility would need to be referenced from experimental data or literature for detailed characterization.

Formula: C₂₁H₂₇NO₄ClH

InChI: InChI=1S/C21H27NO4.ClH/c1-2-12-22-14-18(24)15-26-21-11-9-17(23)13-19(21)20(25)10-8-16-6-4-3-5-7-16;/h3-7,9,11,13,18,22-24H,2,8,10,12,14-15H2,1H3;1H

InChI key: FAYLNKVZLXBDBE-UHFFFAOYSA-N

SMILES: CCCNCC(COC1=C(C=C(C=C1)O)C(=O)CCC2=CC=CC=C2)O.Cl

Synonyms:

• Lu 40-545

5-Hydroxy Propafenone HCl

CAS: 86383-32-6

Formula: C₂₁H₂₇NO₄·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 357.45 36.46

Ref: 4Z-P-151

5-Hydroxypropafenone hydrochloride (Standard)

CAS: 86383-32-6

5-Hydroxypropafenone hydrochloride (Standard) is a reference standard for research and analysis in studies involving 5-Hydroxypropafenone hydrochloride. 5-Hydroxypropafenone, an active metabolite of propafenone, inhibits transient outward potassium current (Ito) in isolated human atrial myocytes with an IC₅₀ of 1.5 µM. In vivo, it increases the atrial effective refractory period in dogs at doses of 0.5, 1, and 2 mg/kg.

Formula: C₂₁H₂₈ClNO₄

Molecular weight: 393.90

Ref: TM-TMSM-3410

5-Hydroxypropafenone Hydrochloride

Controlled Product

CAS: 86383-32-6

Formula: C₂₁H₂₇NO₄·ClH

Color and Shape: Neat

Molecular weight: 393.9

Ref: 86-MM0405.01

5-Hydroxypropafenone Hydrochloride

CAS: 86383-32-6

Formula: C₂₁H₂₇NO₄·ClH

Color and Shape: White To Light Yellow

Molecular weight: 393.9

Ref: 61-FOR0405.01

5-Hydroxy Propafenone Hydrochloride

Controlled Product

CAS: 86383-32-6

Applications A metabolite of Propafenone (P757500).
References Hege, H.G., et al.: Eur. J. Drug Metab. Pharmacokinet., 9, 41 (1984),

Formula: C₂₁H₂₇NO₄·ClH

Color and Shape: Neat

Molecular weight: 393.9

Ref: TR-H952450

5-Hydroxy propafenone hydrochloride

CAS: 86383-32-6

5-Hydroxy propafenone hydrochloride is a drug transporter that has been shown to inhibit the activity of the human organic anion transporting polypeptide (OATP) 1B1 and 1B3. It has been shown to have clinical response in patients with atrial fibrillation. 5-Hydroxy propafenone hydrochloride is eliminated by both renal and hepatic routes, with a terminal half-life of about 10 hours. The compound is also extensively metabolized in humans and its pharmacokinetic properties are well characterized. In vitro studies have demonstrated that this compound has no significant interactions with other drugs used in medical practice. 5-Hydroxy propafenone hydrochloride can be detected in human serum and urine using LC-MS/MS methods. It can also be detected in yeast cells using immunoblotting techniques, which may be utilized for analytical purposes.

Formula: C₂₁H₂₈ClNO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 393.9 g/mol

Ref: 3D-FH24108

5-Hydroxy Propafenone HCL

CAS: 86383-32-6

Formula: C₂₁H₂₈ClNO₄

Molecular weight: 393.9

Ref: BE-MU-7144

5-Hydroxy Propafenone Hydrochloride

CAS: 86383-32-6

Formula: C₂₁H₂₇NO₄HCl

Molecular weight: 357.45 : 36.46

Ref: ST-EA-CP-P55011

5-Hydroxypropafenone hydrochloride

CAS: 86383-32-6

5-Hydroxypropafenone, an active metabolite of propafenone, inhibits transient outward potassium current (Ito) in isolated human atrial myocytes with an IC₅₀ of 1.5 µM. In vivo, it increases the atrial effective refractory period in dogs at doses of 0.5, 1, and 2 mg/kg.

Formula: C₂₁H₂₈ClNO₄

Molecular weight: 393.90

Ref: TM-T207763