CAS 86386-76-7

1-[2-(2,4-Difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole

Description:

1-[2-(2,4-Difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole, with the CAS number 86386-76-7, is a chemical compound characterized by its triazole ring structure, which is a five-membered heterocyclic compound containing three nitrogen atoms. This substance features a difluorophenyl group, contributing to its unique chemical properties and potential biological activity. The presence of an epoxy group indicates that it may participate in reactions typical of epoxides, such as nucleophilic attacks, making it a versatile intermediate in organic synthesis. The compound's structure suggests potential applications in pharmaceuticals or agrochemicals, particularly in the development of fungicides or other crop protection agents. Its fluorinated aromatic moiety may enhance lipophilicity and biological activity. As with many triazole derivatives, it may exhibit antifungal properties, making it of interest in medicinal chemistry. Safety and handling precautions should be observed, as with all chemical substances, due to potential toxicity or environmental impact.

Formula: C₁₁H₉F₂N₃O

InChI: InChI=1S/C11H9F2N3O/c12-8-1-2-9(10(13)3-8)11(5-17-11)4-16-7-14-6-15-16/h1-3,6-7H,4-5H2

InChI key: InChIKey=UIXQTZYZQHYHRL-UHFFFAOYSA-N

SMILES: C(C1(CO1)C2=C(F)C=C(F)C=C2)N3C=NC=N3

Synonyms:

• 1-[2-(2,4-Difluorophenyl)-2,3-Epoxypropyl]-1H-1,2,4-Triazole
• 1-[[2-(2,4-Difluorophenyl)-2-oxiranyl]methyl]-1H-1,2,4-triazole
• 1-[[2-(2,4-Difluorophenyl)oxiranyl]methyl]-1H-1,2,4-triazole
• 1H-1,2,4-Triazole, 1-[[2-(2,4-difluorophenyl)-2-oxiranyl]methyl]-
• 1H-1,2,4-triazole, 1-[[2-(2,4-difluorophenyl)oxiranyl]methyl]-
• 2-(2,4-Difluorophenyl)-2,3-epoxy-1-(1H-1,2,4-triazol-1-yl)propane
• 2-(2,4-Difluorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane
• 1-{[2-(2,4-Difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole

Fluconazole EP Impurity G

CAS: 86386-76-7

Formula: C₁₁H₉F₂N₃O

Molecular weight: 237.21

Ref: ST-EA-CP-F18007

1-[2-(2,4-Difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole

CAS: 86386-76-7

Impurity Fluconazole EP Impurity G
Applications 1-[2-(2,4-Difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole (Fluconazole EP Impurity G) is an epoxy impurity of the antifungal agent Fluconazole (F421000).
References Bourichi, H. et al.: STP Pharm. Prat., 18, 285 (2008); Dongre, V.G. et al.: J. Pharmac. Biomed. Anal., 42, 334 (2006):

Formula: C₁₁H₉F₂N₃O

Color and Shape: Neat

Molecular weight: 237.21

Ref: TR-D446045

1-[2-(2,4-Difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole-d4

Controlled Product

CAS: 86386-76-7

Applications 1-[2-(2,4-Difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole is an epoxy impurity of the antifungal agent Fluconazole (F421000).
References Bourichi, H. et al.: STP Pharm. Prat., 18, 285 (2008); Dongre, V.G. et al.: J. Pharmac. Biomed. Anal., 42, 334 (2006)

Formula: C₁₁D₄H₅F₂N₃O

Color and Shape: Neat

Molecular weight: 241.23

Ref: TR-D446047