CAS 86392-75-8

7-Deaza-2′-deoxyguanosine

Description:

7-Deaza-2′-deoxyguanosine is a modified nucleoside that serves as an analog of deoxyguanosine, where the nitrogen atom at the 7-position of the purine ring is replaced by a carbon atom. This modification alters its biochemical properties, making it of interest in various fields, including molecular biology and medicinal chemistry. The compound is typically characterized by its ability to incorporate into DNA and RNA, potentially influencing nucleic acid structure and function. It exhibits properties that can affect base pairing and stability, which may be leveraged in the design of antiviral and anticancer agents. Additionally, 7-Deaza-2′-deoxyguanosine can be utilized in studies involving DNA replication and repair mechanisms. Its solubility and stability in biological systems are also important characteristics that facilitate its application in research. Overall, this compound represents a valuable tool for investigating nucleic acid interactions and developing therapeutic strategies.

Formula: C₁₁H₁₄N₄O₄

InChI: InChI=1S/C11H14N4O4/c12-11-13-9-5(10(18)14-11)1-2-15(9)8-3-6(17)7(4-16)19-8/h1-2,6-8,16-17H,3-4H2,(H3,12,13,14,18)/t6-,7+,8+/m0/s1

InChI key: InChIKey=PFCLMNDDPTZJHQ-XLPZGREQSA-N

SMILES: O=C1C2=C(N(C=C2)[C@@H]3O[C@H](CO)[C@@H](O)C3)NC(N)=N1

Synonyms:

• 2-Amino-7-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
• 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-7-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-1,7-dihydro-
• 7-Deaza-2'-deoxy-D-guanosine
• 7-Deaza-2'-deoxyguanosine
• 2-Amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
• 98: PN: US20050130918 PAGE: 60 claimed sequence
• 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-1,7-dihydro-

7-Deaza-2'-dG

CAS: 86392-75-8

Formula: C₁₁H₁₄N₄O₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 266.2533

Ref: IN-DA008GG5

2-Amino-7-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-1H-Pyrrolo[2,3-D]Pyrimidin-4(7H)-One

CAS: 86392-75-8

2-Amino-7-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-1H-Pyrrolo[2,3-D]Pyrimidin-4(7H)-One

Purity: 97%

Molecular weight: 266.25g/mol

Ref: 54-OR1010288

7-Deaza-2''-deoxyguanosine

CAS: 86392-75-8

Ref: 7W-GN6984

7-Deaza-2'-deoxyguanosine;  2-Amino-7-(2-deoxy-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one

CAS: 86392-75-8

Nucleoside Derivatives - 7-Deaza-purine nucleoside

Formula: C₁₁H₁₄N₄O₄

Color and Shape: Solid

Molecular weight: 266.25

Ref: TM-TNU1027

7-Deaza-2'-dG

CAS: 86392-75-8

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 266.2569885253906

Ref: 10-F463456

7-Deaza-2'-deoxyguanosine

CAS: 86392-75-8

7-Deaza-2'-deoxyguanosine is an analog of guanosine that has been shown to inhibit the activity of telomerase. This enzyme synthesizes a sequence of DNA called a telomere, which protects the ends of chromosomes from deterioration and prevents chromosomal end-to-end fusion. 7-Deaza-2'-deoxyguanosine has an inhibitory effect on the polymerase chain reaction (PCR) in mammalian cells and inhibits the transcription-polymerase chain reaction (PCR) in vitro. It has also been shown to be potent against cancer cells. 7-Deaza-2'-deoxyguanosine is synthesized by solid phase synthesis, which is a chemical process that involves attaching one molecule to another molecule with similar structure, using organic solvents as intermediates.

Formula: C₁₁H₁₄N₄O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 266.26 g/mol

Ref: 3D-ND02887