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CAS 864731-61-3

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Fluralaner

Description:
Fluralaner is a novel isoxazoline compound primarily used as an insecticide and acaricide in veterinary medicine. It is particularly effective against fleas and ticks in dogs and cats. The substance works by inhibiting the function of certain neurotransmitter receptors, specifically the gamma-aminobutyric acid (GABA) and glutamate-gated chloride channels, leading to paralysis and death of the parasites. Fluralaner is characterized by its long-lasting efficacy, often providing protection for several months with a single dose. It is administered orally or topically, depending on the formulation. The compound is generally well-tolerated in animals, but like all medications, it may have potential side effects, including gastrointestinal disturbances or neurological symptoms in sensitive individuals. Fluralaner is also notable for its low toxicity to mammals, making it a safer option for pet treatment compared to some traditional insecticides. Its chemical structure includes a unique isoxazoline ring, contributing to its mode of action and effectiveness against a broad spectrum of ectoparasites.
Formula:C22H17Cl2F6N3O3
InChI:InChI=1S/C22H17Cl2F6N3O3/c1-11-4-12(2-3-16(11)19(35)31-9-18(34)32-10-21(25,26)27)17-8-20(36-33-17,22(28,29)30)13-5-14(23)7-15(24)6-13/h2-7H,8-10H2,1H3,(H,31,35)(H,32,34)
InChI key:InChIKey=MLBZKOGAMRTSKP-UHFFFAOYSA-N
SMILES:C(F)(F)(F)C1(CC(=NO1)C2=CC(C)=C(C(NCC(NCC(F)(F)F)=O)=O)C=C2)C3=CC(Cl)=CC(Cl)=C3
Synonyms:
  • 4-[5-(3,5-Dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]benzamide
  • 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methyl-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)benzamide
  • AH 252723
  • Benzamide, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-
  • A 1443
  • 4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide
  • Fluralaner
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