CAS 866460-33-5: Setipiprant

Description: Setipiprant is a chemical compound primarily known for its role as a selective antagonist of the prostaglandin D2 receptor 2 (DP2), which is implicated in various allergic and inflammatory conditions. It is classified as a small molecule and has been investigated for its potential therapeutic applications in treating conditions such as asthma and allergic rhinitis. The molecular structure of Setipiprant includes a core that allows for specific binding to the DP2 receptor, thereby inhibiting its activity. This action can lead to a reduction in inflammation and other symptoms associated with allergic responses. Setipiprant is typically administered in oral form and has undergone various clinical trials to assess its efficacy and safety profile. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are important for understanding its therapeutic potential and dosing regimens. Overall, Setipiprant represents a promising avenue in the development of targeted therapies for allergic diseases.

Formula: C₂₄H₁₉FN₂O₃

InChI: InChI=1S/C24H19FN2O3/c25-16-8-9-21-19(12-16)20-13-26(11-10-22(20)27(21)14-23(28)29)24(30)18-7-3-5-15-4-1-2-6-17(15)18/h1-9,12H,10-11,13-14H2,(H,28,29)

InChI key: InChIKey=IHAXLPDVOWLUOS-UHFFFAOYSA-N

SMILES: O=C(O)CN1C=2C=CC(F)=CC2C3=C1CCN(C(=O)C4=CC=CC=5C=CC=CC54)C3

Synonyms:

• ACT 129968
• 2-(2-(1-Naphthoyl)-8-fluoro-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)acetic acid
• Setipiprant
• 8-Fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)-5H-pyrido[4,3-b]indole-5-acetic acid
• 5H-Pyrido[4,3-b]indole-5-acetic acid, 8-fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)-

2-(2-(1-naphthoyl)-8-fluoro-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)acetic acid

CAS: 866460-33-5

• Formula: C₂₄H₁₉FN₂O₃
• Purity: %
• Color and Shape: Solid
• Molecular weight: 402.4177

Setipiprant

CAS: 866460-33-5

• Purity: ≥98%
• Molecular weight: 402.42g/mol

Setipiprant

CAS: 866460-33-5

Setipiprant (ACT-129968) is an oral CRTH2 antagonist for asthma/allergy, targeting PGD2-induced inflammation (IC50: 6.0 nM).

• Formula: C₂₄H₁₉FN₂O₃
• Purity: 99.16%
• Color and Shape: Solid
• Molecular weight: 402.42

Setipiprant(ACT-129968)

CAS: 866460-33-5

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• Formula: C₂₄H₁₉FN₂O₃
• Purity: Min. 95%
• Molecular weight: 402.42 g/mol