CAS 868272-50-8

Formula: C19H20N8O2

InChI: InChI=1S/C19H20N8O2/c1-10(2)22-16-13(9-20)17(26-19(21)25-16)23-14-8-12(5-4-11(14)3)18(28)24-15-6-7-29-27-15/h4-8,10H,1-3H3,(H,24,27,28)(H4,21,22,23,25,26)

InChI key: VXWYKMMJKQFNRP-UHFFFAOYSA-N

SMILES: CC1=C(C=C(C=C1)C(=O)NC2=NOC=C2)NC3=C(C(=NC(=N3)N)NC(C)C)C#N

p38-α MAPK-IN-9

CAS: 868272-50-8

p38-α MAPK-IN-9 (Compound 25a) is a p38-α MAPK inhibitor with a Ki value of 0.057 nM. It effectively inhibits LPS-induced TNFα production in hPBMC cells, exhibiting an IC₅₀ of 18 nM.

Formula: C₁₉H₂₀N₈O₂

Color and Shape: Solid

Molecular weight: 392.414

Ref: TM-T205389