CAS 868540-17-4
:Carfilzomib
Description:
Carfilzomib is a synthetic peptide epoxyketone and a selective proteasome inhibitor, primarily used in the treatment of multiple myeloma. Its chemical formula is C22H30N4O5, and it has a molecular weight of approximately 426.5 g/mol. Carfilzomib functions by irreversibly binding to the proteasome, leading to the accumulation of pro-apoptotic factors and ultimately inducing apoptosis in cancer cells. It is administered intravenously and is known for its potency and specificity, which minimizes off-target effects compared to other proteasome inhibitors. The substance is characterized by its unique structure, which includes a cyclic peptide backbone and an epoxyketone moiety that is crucial for its mechanism of action. Carfilzomib is typically used in patients who have received prior therapies, and its side effects may include fatigue, anemia, and cardiovascular issues. Overall, Carfilzomib represents a significant advancement in targeted cancer therapy, particularly for patients with relapsed or refractory multiple myeloma.
Formula:C40H57N5O7
InChI:InChI=1/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1
Synonyms:- Px-171-007
- N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninamide
- (S)-2-((S)-2-(2-(2H-1,4-oxazin-4(3H)-yl) acetamido)-4-phenylbutanamide)-4-methyl-N-((S)-1-((S)-4-methyl-1-((R)-2-methyl oxiran-2-yl)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)pentanamide
- Carfilzomib(PR-171)
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Found 13 products.
(S)-4-Methyl-N-((S)-1-(((S)-4-Methyl-1-((R)-2-Methyloxiran-2-Yl)-1-Oxopentan-2-Yl)Amino)-1-Oxo-3-Phenylpropan-2-Yl)-2-((S)-2-(2-Morpholinoacetamido)-4-Phenylbutanamido)Pentanamide
CAS:(S)-4-Methyl-N-((S)-1-(((S)-4-Methyl-1-((R)-2-Methyloxiran-2-Yl)-1-Oxopentan-2-Yl)Amino)-1-Oxo-3-Phenylpropan-2-Yl)-2-((S)-2-(2-Morpholinoacetamido)-4-Phenylbutanamido)PentanamidePurity:98%，ee98%Molecular weight:719.91g/molCarfilzomib
CAS:Formula:C40H57N5O7Purity:(HPLC) ≥ 98.0%Color and Shape:White to off-white crystalline powder or crystalsMolecular weight:719.91Carfilzomib
CAS:Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome.Formula:C40H57N5O7Purity:99.6% - 99.84%Color and Shape:SolidMolecular weight:719.91Carfilzomib
CAS:Controlled ProductApplications Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);Formula:C40H57N5O7Color and Shape:White To Off-WhiteMolecular weight:719.917(R)-epi Carfilzomib (2R,4R)-Diol
CAS:Controlled ProductFormula:C40H59N5O8Color and Shape:NeatMolecular weight:737.9257(R)-epi Carfilzomib (2R,4S)-diol
CAS:Controlled ProductFormula:C40H59N5O8Color and Shape:NeatMolecular weight:737.9257(R)-epi Carfilzomib (2S,4S)-Diol
CAS:Controlled ProductFormula:C40H59N5O8Color and Shape:NeatMolecular weight:737.9257(R)-epi Carfilzomib (2S,4R)-diol
CAS:Controlled ProductFormula:C40H59N5O8Color and Shape:NeatMolecular weight:737.925Carfilzomib
CAS:Inhibits proteosomes of class peptide epoxyketone; antineoplastic
Formula:C40H57N5O7Purity:Min. 95%Color and Shape:PowderMolecular weight:719.91 g/mol
