CAS 868540-17-4

Carfilzomib

Description:

Carfilzomib is a synthetic peptide epoxyketone and a selective proteasome inhibitor, primarily used in the treatment of multiple myeloma. Its chemical formula is C22H30N4O5, and it has a molecular weight of approximately 426.5 g/mol. Carfilzomib functions by irreversibly binding to the proteasome, leading to the accumulation of pro-apoptotic factors and ultimately inducing apoptosis in cancer cells. It is administered intravenously and is known for its potency and specificity, which minimizes off-target effects compared to other proteasome inhibitors. The substance is characterized by its unique structure, which includes a cyclic peptide backbone and an epoxyketone moiety that is crucial for its mechanism of action. Carfilzomib is typically used in patients who have received prior therapies, and its side effects may include fatigue, anemia, and cardiovascular issues. Overall, Carfilzomib represents a significant advancement in targeted cancer therapy, particularly for patients with relapsed or refractory multiple myeloma.

Formula: C₄₀H₅₇N₅O₇

InChI: InChI=1/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1

InChI key: BLMPQMFVWMYDKT-NZTKNTHTSA-N

SMILES: CC(C)C[C@@H](C(=O)[C@]1(CO1)C)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC3=CC=CC=C3)NC(=O)CN4CCOCC4

Synonyms:

• Px-171-007
• N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninamide
• (S)-2-((S)-2-(2-(2H-1,4-oxazin-4(3H)-yl) acetamido)-4-phenylbutanamide)-4-methyl-N-((S)-1-((S)-4-methyl-1-((R)-2-methyl oxiran-2-yl)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)pentanamide
• Carfilzomib(PR-171)

Carfilzomib

CAS: 868540-17-4

Carfilzomib

Formula: C₄₀H₅₇N₅O₇

Purity: ≥98%

Molecular weight: 719.91

Ref: 54-BUP06068

(S)-4-Methyl-N-((S)-1-(((S)-4-Methyl-1-((R)-2-Methyloxiran-2-Yl)-1-Oxopentan-2-Yl)Amino)-1-Oxo-3-Phenylpropan-2-Yl)-2-((S)-2-(2-Morpholinoacetamido)-4-Phenylbutanamido)Pentanamide

CAS: 868540-17-4

(S)-4-Methyl-N-((S)-1-(((S)-4-Methyl-1-((R)-2-Methyloxiran-2-Yl)-1-Oxopentan-2-Yl)Amino)-1-Oxo-3-Phenylpropan-2-Yl)-2-((S)-2-(2-Morpholinoacetamido)-4-Phenylbutanamido)Pentanamide

Formula: C₄₀H₅₇N₅O₇

Purity: 98%,98%ee

Molecular weight: 719.91

Ref: 54-OR1023056

Carfilzomib

CAS: 868540-17-4

Formula: C₄₀H₅₇N₅O₇

Color and Shape: White To Off-White Solid

Molecular weight: 719.92

Ref: 4Z-C-121001

Carfilzomib

CAS: 868540-17-4

Formula: C₄₀H₅₇N₅O₇

Color and Shape: Neat

Molecular weight: 719.91

Ref: 86-MM3929.00

Carfilzomib

Controlled Product

CAS: 868540-17-4

Applications Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);

Formula: C₄₀H₅₇N₅O₇

Color and Shape: Neat

Molecular weight: 719.91

Ref: TR-C183460

Carfilzomib

CAS: 868540-17-4

Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome.

Formula: C₄₀H₅₇N₅O₇

Purity: 99.6% - 99.92%

Color and Shape: White Solid

Molecular weight: 719.9099

Ref: TM-T1795

Carfilzomib

CAS: 868540-17-4

(S)-4-Methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide

Formula: C₄₀H₅₇N₅O₇

Purity: 98%

Molecular weight: 719.91

Ref: IN-DG292920

Carfilzomib

CAS: 868540-17-4

Formula: C₄₀H₅₇N₅O₇

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white crystalline powder or crystals

Molecular weight: 719.91

Ref: 7W-GP8753

Carfilzomib

CAS: 868540-17-4

Formula: C₄₀H₅₇N₅O₇

Molecular weight: 719.92

Ref: ST-EA-CP-C153000

Carfilzomib

CAS: 868540-17-4

Inhibits proteosomes of class peptide epoxyketone; antineoplastic

Formula: C₄₀H₅₇N₅O₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 719.91 g/mol

Ref: 3D-FC46443

Carfilzomib

CAS: 868540-17-4

Formula: C₄₀H₅₇N₅O₇

Molecular weight: 719.9

Ref: BE-RMCC087000

Carfilzomib

CAS: 868540-17-4

Purity: 98%

Molecular weight: 719.9240112

Ref: 10-F951459

7(R)-epi Carfilzomib (2R,4S)-diol

Controlled Product

CAS: 868540-17-4

Formula: C₄₀H₅₉N₅O₈

Color and Shape: Neat

Molecular weight: 737.925

Ref: TR-C183472

7(R)-epi Carfilzomib (2S,4S)-Diol

Controlled Product

CAS: 868540-17-4

Formula: C₄₀H₅₉N₅O₈

Color and Shape: Neat

Molecular weight: 737.925

Ref: TR-C183471

7(R)-epi Carfilzomib (2S,4R)-diol

Controlled Product

CAS: 868540-17-4

Formula: C₄₀H₅₉N₅O₈

Color and Shape: Neat

Molecular weight: 737.925

Ref: TR-C183473

7(R)-epi Carfilzomib (2R,4R)-Diol

Controlled Product

CAS: 868540-17-4

Formula: C₄₀H₅₉N₅O₈

Color and Shape: Neat

Molecular weight: 737.925

Ref: TR-C183474