CAS 87-13-8

Diethyl (ethoxymethylene)malonate

Description:

Diethyl (ethoxymethylene)malonate, with the CAS number 87-13-8, is an organic compound that belongs to the class of malonates, which are esters derived from malonic acid. This substance typically appears as a colorless to pale yellow liquid and is known for its distinctive fruity odor. It is soluble in organic solvents such as ethanol and ether but has limited solubility in water. The compound features two ethyl groups and an ethoxymethylene group attached to the malonate backbone, which contributes to its reactivity in various chemical reactions, particularly in the synthesis of other organic compounds. Diethyl (ethoxymethylene)malonate is often utilized in organic synthesis, especially in the formation of carbon-carbon bonds through reactions like the Michael addition and the Claisen condensation. Additionally, it serves as a building block in the synthesis of pharmaceuticals and agrochemicals. As with many organic compounds, proper handling and safety precautions are essential due to potential health hazards associated with exposure.

Formula: C₁₀H₁₆O₅

InChI: InChI=1S/C10H16O5/c1-4-13-7-8(9(11)14-5-2)10(12)15-6-3/h7H,4-6H2,1-3H3

InChI key: InChIKey=LTMHNWPUDSTBKD-UHFFFAOYSA-N

SMILES: C(C(OCC)=O)(C(OCC)=O)=COCC

Synonyms:

• (Aethoxymethylen)-Malonsaeure-Diaethylester
• (Ethoxymethylene)malonic acid diethyl ester
• (Ethoxymethylene)propanedioic acid diethyl ester
• 1,1-Dicarboethoxy-2-ethoxyethylene
• 1,3-Diethyl 2-(ethoxymethylidene)propanedioate
• 2-(Ethoxymethylene)malonic acid diethyl ester
• 2-Ethoxy-1,1-bis(ethoxycarbonyl)ethene
• Diethyl (Ethoxymethylidene)Propanedioate
• Diethyl (ethoxymethylene)malonate
• Diethyl (ethoxymethylene)propanedioate
• Diethyl 2-(Ethoxymethylene)Malonate
• Diethyl 2-(ethoxymethylene)propanedioate
• Diethyl 2-(ethoxymethylidene)propanedioate
• Diethyl 2-[(ethyloxy)methylidene]propanedioate
• Diethyl 2-ethoxymethylidene malonate
• Diethyl ethoxymethylidenemalonate
• Diethyl[(ethyloxy)methylidene]propanedioate
• Diethylethoxymethylenmalonat
• Emme
• Ethoxymethylenemalonate de diethyle
• Ethoxymethylenmalonic acid diethylester
• Ethyl 3-ethoxy-2-(ethoxymethylene)-3-oxopropanoate
• Etoximetilenmalonato De Dietilo
• Malonic acid, (ethoxymethylene)-, diethyl ester
• Nsc 62117
• Nsc 9068
• Propanedioic acid, 2-(ethoxymethylene)-, 1,3-diethyl ester
• Propanedioic acid,(ethoxymethylene)-, diethyl ester

Diethyl ethoxymethylenemalonate, 98+%

CAS: 87-13-8

Diethyl ethoxymethylenemalonate is used for synthesis of pyrido[3,2-e]pyrimido[1,2-c]pyrimidines. Initially, it was used to monitor lysine decarboxylase activity. It is useful in the determination of amino acids by precolumn derivatization by using reversed-phase high-performance liquid chromatograp

Formula: C₁₀H₁₆O₅

Purity: 98+%

Color and Shape: Clear colorless, Liquid

Molecular weight: 216.23

Ref: 02-A13776

Diethyl Ethoxymethylenemalonate

CAS: 87-13-8

Formula: C₁₀H₁₆O₅

Purity: 98%

Color and Shape: Liquid

Molecular weight: 216.2310

Ref: IN-DA0034QA

Diethyl ethoxymethylenemalonate

CAS: 87-13-8

Diethyl ethoxymethylenemalonate

Formula: C₁₀H₁₆O₅

Purity: >99%

Molecular weight: 216.23

Ref: 54-OR1012869

Diethyl ethoxymethylenemalonate

CAS: 87-13-8

Formula: C₁₀H₁₆O₅

Purity: ≥ 99.0%

Color and Shape: Clear, colourless liquid

Molecular weight: 216.23

Ref: 7W-GX3867

Diethyl ethoxymethylidenemalonate

CAS: 87-13-8

Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication.

Formula: C₁₀H₁₆O₅

Purity: Min. 95%

Color and Shape: Colorless Clear Liquid

Molecular weight: 216.23 g/mol

Ref: 3D-FD21796

Diethyl ethoxymethylene malonate

CAS: 87-13-8

Formula: C₁₀H₁₆O₅

Purity: 98%

Color and Shape: Liquid, Clear

Molecular weight: 216.233

Ref: 10-F037363

Diethyl 2-(ethoxymethylene)malonate

CAS: 87-13-8

Diethyl 2-(ethoxymethylene)malonate

Formula: C₁₀H₁₆O₅

Purity: 98%

Molecular weight: 216.23

Ref: IN-DG22928

Diethyl Ethoxymethylidenemalonate

CAS: 87-13-8

Applications Intermediate in the production of Flumequine
References Sato, M., et al.: J. Med. Chem., 52, 4869 (2009),

Formula: C₁₀H₁₆O₅

Color and Shape: Neat

Molecular weight: 216.23

Ref: TR-D444300

Nalidixic acid impurity C

CAS: 87-13-8

Formula: C₁₀H₁₆O₅

Molecular weight: 216.23

Ref: ST-EA-CP-N19003

Diethyl Ethoxymethylenemalonate

CAS: 87-13-8

Formula: C₁₀H₁₆O₅

Purity: >97.0%(GC)

Color and Shape: Colorless to Light yellow clear liquid

Molecular weight: 216.23

Ref: 3B-E0255