CAS 87-33-2

Isosorbide dinitrate

Description:

Isosorbide dinitrate (ISDN) is an organic nitrate compound primarily used as a vasodilator in the treatment of angina pectoris and heart failure. It is a colorless to pale yellow crystalline solid that is soluble in water and organic solvents. The chemical formula for isosorbide dinitrate is C7H10N2O5, and it features two nitrate groups esterified to the isosorbide backbone. ISDN acts by releasing nitric oxide, which relaxes vascular smooth muscle, leading to the dilation of blood vessels and improved blood flow. The compound is typically administered in oral or sublingual forms, and its pharmacokinetics include a rapid onset of action with a relatively short half-life. Common side effects may include headaches, dizziness, and hypotension. Due to its potential for tolerance development, dosing regimens often involve intermittent use. Isosorbide dinitrate is also utilized in research settings to study vascular function and nitric oxide signaling pathways. Safety precautions are necessary when handling this compound, as it can be sensitive to heat and shock.

Formula: C₆H₈N₂O₈

InChI: InChI=1/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2/t3-,4+,5-,6-/m1/s1

InChI key: InChIKey=MOYKHGMNXAOIAT-JGWLITMVSA-N

SMILES: O(N(=O)=O)[C@H]1[C@@]2([C@@]([C@@H](ON(=O)=O)CO2)(OC1)[H])[H]

Synonyms:

• 1,4,3,6-Sorbido-2,5-dinitric acid ester
• 1,4:3,6-Dianhydro-<span class="text-smallcaps">D</span>-glucitol 2,5-dinitrate
• 1,4:3,6-Dianhydro-<span class="text-smallcaps">D</span>-sorbitol 2,5-dinitrate
• 1,4:3,6-Dianhydro-D-glucitol 2,5-dinitrate
• 1,4:3,6-Dianhydro-D-sorbitol 2,5-dinitrate
• 1,4:3,6-Dianhydrosorbitol 2,5-dinitrate
• <span class="text-smallcaps">D</span>-Glucitol, 1,4:3,6-dianhydro-, 2,5-dinitrate
• <span class="text-smallcaps">D</span>-Glucitol, 1,4:3,6-dianhydro-, dinitrate
• <span class="text-smallcaps">D</span>-Isosorbide dinitrate
• Astridine
• Cardiket
• Cardio 10
• Cardis
• Carvanil
• Carvasin
• Cedocard
• Claodical
• Corosorbide
• Corovliss
• D-Glucitol, 1,4:3,6-dianhydro-, 2,5-dinitrate
• D-Isosorbide dinitrate
• Dignionitrat
• Dilatrate
• Dilatrate SR
• Diniket
• Dinitrate d'isosorbide
• Dinitrato De Isosorbida
• Dinitroisosorbide
• Dinitrosorbide
• Disorlon
• Duranitrat
• EureCor
• Ev 151
• Flindix
• Frandol
• Furo[3,2-b]furan, <span class="text-smallcaps">D</span>-glucitol deriv.
• Glentonin
• Glucitol, 1,4:3,6-dianhydro-, dinitrate
• Glucitol, 1,4:3,6-dianhydro-, dinitrate, <span class="text-smallcaps">D</span>-
• Glucitol, 1,4:3,6-dianhydro-, dinitrate, D-
• Harrical
• IBD
• Imtack
• Isdin
• Isdn
• Iso-Bid
• Iso-Mack
• Iso-Puren
• Isocard
• Isocore
• Isodinit
• Isoket
• Isoket retard 40
• Isonate?
• Isorbid
• Isordil
• Isordil Tembids
• Isosorbiddinitrat
• Isosorbide 2,5-dinitrate
• Isosorbide Dinitrate
• Isosorbide dinitrate mixture
• Isosorbide nitrate
• Isostenase
• Isotrate
• Korodil
• Langoran
• Laserdil
• Maycor
• Mixture, Isosorbide Dinitrate
• Myorexon
• Nitorol
• Nitrofix
• Nitrol
• Nitrosorbid
• Nitrosorbide
• Nitrosorbonl Nosim
• Nsc 80038
• Resoidan
• Rifloc Retard
• Rigedal
• Risordan
• Sdm 25
• Sdm 40
• Soni-Slo
• Sorbangil
• Sorbichew
• Sorbid SA
• Sorbide dinitrate
• Sorbide nitrate
• Sorbidilat
• Sorbidnitrate
• Sorbitol, 1,4:3,6-dianhydro-, dinitrate
• Sorbitrate
• Sorbonit
• Sorbopercuten
• Sorquad
• Tyb 3215
• Vascardin
• Vasorbate
• Vasotrate
• 1,4:3,6-dianhydro-2,5-di-O-nitrohexitol
• D-Glucitol, 1,4:3,6-dianhydro-, dinitrate
• 1,4:3,6-dianhydro-2,5-di-O-nitro-D-glucitol
• Isosobide dinitrate
• 1,4:3,6-dianhydrosorbitol2,5-dinitrate
• 1,4:3,6-dianhydro-,dinitrate,d-glucito
• 1,4:3,6-dianhydro-d-glucitodinitrate
• dianhydrosorbitol2,5-dinitrate
• isochron

ISOSORBIDE DINITRATE CRS

CAS: 87-33-2

ISOSORBIDE DINITRATE CRS

Formula: C₆H₈N₂O₈

Color and Shape: Powder.

Molecular weight: 236.1363

Ref: 41-I0775000

Diluted Isosorbide Dinitrate

CAS: 87-33-2

Heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Formula: C₆H₈N₂O₈

Color and Shape: White Powder

Molecular weight: 236.02807

Ref: 45-1353000

Isosorbide dinitrate

CAS: 87-33-2

Formula: C₆H₈N₂O₈

Purity: 95%

Color and Shape: Solid

Molecular weight: 236.1363

Ref: IN-DA003R5M

Isosorbide dinitrate

CAS: 87-33-2

Formula: C₆H₈N₂O₈

Purity: ≥ 98% (isosorbide dinitrate)

Color and Shape: White to off-white powder

Molecular weight: 236.14

Ref: 7W-GC6329

Isosorbide dinitrate

CAS: 87-33-2

Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris.

Formula: C₆H₈N₂O₈

Purity: 99.87%

Color and Shape: Hard Colorless Crystals Solid

Molecular weight: 236.14

Ref: TM-T1479

Isosorbide dinitrate - 60% lactose and 40% Isosorbide dinitrate

CAS: 87-33-2

Isosorbide dinitrate is used to treat chronic bronchitis and congestive heart failure. It dilates blood vessels, allowing more oxygen-rich blood to reach the heart. Isosorbide dinitrate is also used to relieve chest pain (angina) and reduce complications after a heart attack. Isosorbide dinitrate is a prodrug that is converted in vivo to its active form, isosorbide mononitrate, by the enzyme nitric oxide synthase in response to hypoxia. In addition, it has been shown that this drug reduces levels of low-density lipoprotein cholesterol (LDL-C) and may be useful for the treatment of high cholesterol.
The mechanism of action for reducing LDL-C levels is not known but may be due to increased clearance of LDL-C from plasma or decreased production of very low density lipoproteins (VLDL). This medication does not affect triglycerides or high density lip

Formula: C₆H₈N₂O₈

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 236.14 g/mol

Ref: 3D-MI09907

Isosorbide Mononitrate EP Impurity A

CAS: 87-33-2

Formula: C₆H₈N₂O₈

Molecular weight: 236.14

Ref: ST-EA-CP-I24001

Isosorbide Dinitrate

CAS: 87-33-2

Formula: C₆H₈N₂O₈

Molecular weight: 236.14

Ref: 4Z-I-194