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CAS 87-33-2

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Isosorbide dinitrate

Description:
Isosorbide dinitrate (ISDN) is an organic nitrate compound primarily used as a vasodilator in the treatment of angina pectoris and heart failure. It is a colorless to pale yellow crystalline solid that is soluble in water and organic solvents. The chemical formula for isosorbide dinitrate is C7H10N2O5, and it features two nitrate groups esterified to the isosorbide backbone. ISDN acts by releasing nitric oxide, which relaxes vascular smooth muscle, leading to the dilation of blood vessels and improved blood flow. The compound is typically administered in oral or sublingual forms, and its pharmacokinetics include a rapid onset of action with a relatively short half-life. Common side effects may include headaches, dizziness, and hypotension. Due to its potential for tolerance development, dosing regimens often involve intermittent use. Isosorbide dinitrate is also utilized in research settings to study vascular function and nitric oxide signaling pathways. Safety precautions are necessary when handling this compound, as it can be sensitive to heat and shock.
Formula:C6H8N2O8
InChI:InChI=1/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2/t3-,4+,5-,6-/m1/s1
InChI key:InChIKey=MOYKHGMNXAOIAT-JGWLITMVSA-N
SMILES:O(N(=O)=O)[C@H]1[C@@]2([C@@]([C@@H](ON(=O)=O)CO2)(OC1)[H])[H]
Synonyms:
  • 1,4,3,6-Sorbido-2,5-dinitric acid ester
  • 1,4:3,6-Dianhydro-<span class="text-smallcaps">D</span>-glucitol 2,5-dinitrate
  • 1,4:3,6-Dianhydro-<span class="text-smallcaps">D</span>-sorbitol 2,5-dinitrate
  • 1,4:3,6-Dianhydro-D-glucitol 2,5-dinitrate
  • 1,4:3,6-Dianhydro-D-sorbitol 2,5-dinitrate
  • 1,4:3,6-Dianhydrosorbitol 2,5-dinitrate
  • <span class="text-smallcaps">D</span>-Glucitol, 1,4:3,6-dianhydro-, 2,5-dinitrate
  • <span class="text-smallcaps">D</span>-Glucitol, 1,4:3,6-dianhydro-, dinitrate
  • <span class="text-smallcaps">D</span>-Isosorbide dinitrate
  • Astridine
  • See more synonyms
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