CAS 870281-82-6: Idelalisib

Description: Idelalisib is a selective inhibitor of phosphoinositide 3-kinase (PI3K) delta, primarily used in the treatment of certain types of hematological malignancies, particularly chronic lymphocytic leukemia (CLL) and follicular lymphoma. Its chemical formula is C19H19ClN2O4S, and it features a chlorobenzene ring, a pyrimidine moiety, and a sulfonamide group, which contribute to its pharmacological activity. Idelalisib works by disrupting the signaling pathways that promote cell proliferation and survival in malignant B cells. The substance is administered orally and is known for its potential side effects, including diarrhea, liver function abnormalities, and immune-related adverse events. As a targeted therapy, idelalisib represents a significant advancement in the treatment of specific cancers, offering a more focused approach compared to traditional chemotherapy. Its development underscores the importance of molecular targeting in oncology, aiming to improve patient outcomes while minimizing systemic toxicity.

Formula: C₂₂H₁₈FN₇O

InChI: InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1

InChI key: InChIKey=IFSDAJWBUCMOAH-HNNXBMFYSA-N

SMILES: O=C1C=2C(F)=CC=CC2N=C(N1C=3C=CC=CC3)C(NC4=NC=NC=5N=CNC54)CC

Synonyms:

• (S)-2-(1-((9H-Purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
• 4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(1H-purin-6-ylamino)propyl]-
• 4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-
• 5-Fluoro-3-Phenyl-2-[(1S)-1-(9H-Purin-6-Ylamino)Propyl]-4(3H)-Quinazolinone
• Cal-101
• Delalisib
• Gs-1101
• Idelalisib
• N⁶-[(S)-1-(5-Fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]adenine
• Zydelig

4(3H)-Quinazolinone,5-fluoro-3-phenyl-2-[(1S)-1-(1H-purin-6-ylamino)propyl]-

CAS: 870281-82-6

• Formula: C₂₂H₁₈FN₇O
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 415.423

Idelalisib

CAS: 870281-82-6

• Formula: C₂₂H₁₈FN₇O
• Color and Shape: White To Off-White Solid
• Molecular weight: 415.43

Idelalisib

CAS: 870281-82-6

• Purity: 99.93%
• Molecular weight: 415.42g/mol

5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone

CAS: 870281-82-6

• Purity: 98%
• Molecular weight: 415.42g/mol

Idelalisib

CAS: 870281-82-6

• Color and Shape: Neat

Idelalisib

CAS: 870281-82-6

Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 …

• Formula: C₂₂H₁₈FN₇O
• Purity: 98% - 99.39%
• Color and Shape: Solid
• Molecular weight: 415.42

Idelalisib-d5

CAS: 870281-82-6

• Formula: C₂₂H₁₃FN₇OD₅
• Molecular weight: 420.46

CAL-101

CAS: 870281-82-6

Applications CAL-101 is a PI3K/mTOR pathway inhibitor used in the treatment of myeloid leukemia through …

• Formula: C₂₂H₁₈FN₇O
• Color and Shape: Light Brown
• Molecular weight: 415.40

(S)-2-(1-((9H-Purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one

CAS: 870281-82-6

• Purity: 95.0%
• Color and Shape: Solid
• Molecular weight: 415.4320068359375

Idelalisib

CAS: 870281-82-6

Please enquire for more information about Idelalisib including the price, delivery time and more detailed …

• Formula: C₂₂H₁₈FN₇O
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 415.42 g/mol

CAL-101-d5

CAS: 870281-82-6

• Formula: C₂₂D₅H₁₃FN₇O
• Color and Shape: Neat
• Molecular weight: 420.454